Neuropsychological and Behavioral Testing in Younger Patients With Cancer

PRIMARY OBJECTIVES:

I. To utilize a standardized battery of age-appropriate neuropsychological and behavioral
tests in conjunction with Children's Oncology Group (COG) Phase II and III clinical trials to
evaluate cognitive, social, emotional, and behavioral functioning over time.

II. To institute procedures to ensure a consistent, streamlined, and efficient administration
of the neuropsychological/behavioral tests in a cooperative group setting in order to
maximize compliance with a standardized assessment battery conducted at 3 standardized time
points.

OUTLINE:

Parent and child participants complete the COG Standard Neuropsychological and Behavioral
Battery testing at 9, 30, and 60 months post-diagnosis in a 1-2 hour session conducted by a
neuropsychologist or psychologist. The Battery consists of tests of intelligence, processing
speed/attention, memory, language preference, general developmental progress, attention and
behavior/social/emotional function, executive function, adoptive function, and quality of
life. Additionally, parents complete a parent-report questionnaire to gather information
about patient's function in terms of attention, memory, executive abilities, and behavioral,
social, and emotional adaption.

Inclusion Criteria:

- The patient must be currently be enrolled or plan to be enrolled on a COG therapeutic
study that aims to examine neuropsychological, social, emotional, and/or behavioral
functioning

- The patient must have receptive and expressive language skills in English, French, or
Spanish; if a patient meets these criteria but the parent/guardian speaks a language
other than English, French, or Spanish, the patient may still be enrolled and tested,
and the parent-report measures should be omitted

- All patients and/or their parents or legal guardians must sign a written informed
consent

- All institutional, Food and Drug Administration (FDA), and National Cancer Institute
(NCI) requirements for human studies must be met

Exclusion Criteria:

- Patients with a history of moderate to profound intellectual disability (i.e.
intelligence quotient [IQ] =< 55) are not eligible for enrollment; PLEASE NOTE:
Children with a prior history of attention deficit hyperactivity disorder (ADHD) or a
specific learning disability (e.g. dyslexia) are eligible for this study