Sex and Obesity: Effects on Heart Failure Study
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 65 |
| Updated: | 6/8/2018 |
| Start Date: | January 2008 |
| End Date: | February 2019 |
Sex and Obesity Effects on Myocardial Blood Flow and Metabolism
Sex has a major impact on myocardial metabolism and blood flow. In subjects without heart
failure men's hearts tend to use proportionally more glucose and women's hearts use more fat
and have higher blood flow.
Obesity is a major risk factor for Heart Failure. In subjects without heart failure,
increasing body mass index is predictive of increased blood flow and fatty acid metabolism in
women, but not men.
To measure blood flow and metabolism we will be using radioactive materials and a PET
(positron emission Tomography)scan to study the metabolism of the heart.
Hypotheses: 1) Women with nonischemic heart failure will have higher levels of heart blood
flow and fatty acid metabolism and lower glucose metabolism rates than men with nonischemic
heart failure 2) Patients with obesity-related HF have a myocardial metabolic profile that is
similar to that of obese subjects without heart failure and different (higher FA metabolism)
from that of nonobese Heart failure patients.
failure men's hearts tend to use proportionally more glucose and women's hearts use more fat
and have higher blood flow.
Obesity is a major risk factor for Heart Failure. In subjects without heart failure,
increasing body mass index is predictive of increased blood flow and fatty acid metabolism in
women, but not men.
To measure blood flow and metabolism we will be using radioactive materials and a PET
(positron emission Tomography)scan to study the metabolism of the heart.
Hypotheses: 1) Women with nonischemic heart failure will have higher levels of heart blood
flow and fatty acid metabolism and lower glucose metabolism rates than men with nonischemic
heart failure 2) Patients with obesity-related HF have a myocardial metabolic profile that is
similar to that of obese subjects without heart failure and different (higher FA metabolism)
from that of nonobese Heart failure patients.
Inclusion Criteria: men and women
- Non Ischemic Heart failure, ejection fraction <40%, premenopausal, Obese(BMI
>30),Lean, age 20-50, non diabetic
Exclusion Criteria:
- Pregnancy, lactating, actively losing weight, nonsedentary, greater than Class I
hypertension,require alterations in heart medications, Diabetics.
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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