Phase 1 Study of Radiosensitization Using Bortezomib in Relapsed Non-Hodgkin's Lymphoma Patients Receiving Radioimmunotherapy

Inclusion Criteria:

- Patients must have histologically proven relapsed or refractory MCL, DLBCL including
subtypes mediastinal large B cell, centroblastic, immunoblastic, T cell rich B cell
and anaplastic large B cell lymphoma, or low grade B cell NHL.

- Patients must have received prior systemic therapy for their lymphoma.

- Age >18 years.

- Life expectancy of greater than 12 weeks

- Women of child-bearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry and for
the duration of study participation. Should a woman become pregnant or suspect she is
pregnant while participating in this study, she should inform her treating physician
immediately.

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Patients may not be receiving any other investigational agents.

- Patients with known brain metastases should be excluded from this clinical trial
because of their poor prognosis and because they often develop progressive neurologic
dysfunction that would confound the evaluation of neurologic and other adverse events.

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to bortezomib or boron.

- Previous radiation therapy to the maximum tissue tolerance at any site.

- Previous autologous or allogeneic stem cell transplantation.

- Involvement of the bone marrow of >25% by lymphoma.

- Known involvement of the central nervous system by lymphoma. 17

- Significant organ dysfunction, including hematologic (absolute neutrophil count <1500,
platelets <150,000).

- ECOG performance status >2.

- Uncontrolled illness including, but not limited to, ongoing or active
infection,symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.

- HIV infection.

- Patient has a calculated or measured creatinine clearance of <20 mL/minute within 14
days before enrollment.

- Patient has ≥Grade 2 peripheral neuropathy within 14 days before enrollment.

- Myocardial infarction within 3 months prior to enrollment or has New York Heart
Association (NYHA) Class III or IV heart failure (see section 8.4), uncontrolled
angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence
of acute ischemia or active conduction system abnormalities. Prior to study entry, any
ECG abnormality at screening has to be documented by the investigator as not medically
relevant.

- Patient has hypersensitivity to bortezomib, boron or mannitol.

- Female subject is pregnant or breast-feeding. Confirmation that the subject is not
pregnant must be established by a negative serum β-human chorionic gonadotropin
(β-hCG) pregnancy test result obtained during screening. Pregnancy testing is not
required for post-menopausal or surgically sterilized women.