Caloric Restriction, Exercise, and Glucoregulation in Humans
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 45 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | April 2008 |
| End Date: | March 2015 |
Weight loss induced by caloric restriction alone (CR) and by exercise alone (EX) result in
similar effects on blood glucose and insulin. The purpose of this study is to assess the
hypothesis that weight loss through caloric restriction plus exercise will result in greater
improvements on glucose tolerance and insulin action than similar weight losses through CR
or EX alone.
similar effects on blood glucose and insulin. The purpose of this study is to assess the
hypothesis that weight loss through caloric restriction plus exercise will result in greater
improvements on glucose tolerance and insulin action than similar weight losses through CR
or EX alone.
Participants are randomized into caloric restriction, exercise, and caloric restriction plus
exercise weight loss groups. Measurements of blood glucose and insulin, oral glucose
tolerance, and matched glucose infusion will be done at baseline and after weight loss of 6%
of body weight. Other tests include maximal oxygen uptake (VO2max), strength tests, blood
pressure, blood lipids, serum inflammatory markers, dual X-ray absorptiometry (DEXA) for
bone density and body composition, physical activity levels, dietary intakes, and measures
of arterial stiffness.
exercise weight loss groups. Measurements of blood glucose and insulin, oral glucose
tolerance, and matched glucose infusion will be done at baseline and after weight loss of 6%
of body weight. Other tests include maximal oxygen uptake (VO2max), strength tests, blood
pressure, blood lipids, serum inflammatory markers, dual X-ray absorptiometry (DEXA) for
bone density and body composition, physical activity levels, dietary intakes, and measures
of arterial stiffness.
Inclusion Criteria:
- females postmenopausal
- no diabetes, cardiovascular disease, cancer
- no orthopedic problems
- not currently exercising
- BMI between 25 and 29.9
- nonsmokers
Exclusion Criteria:
- current regular exercisers
- premenopausal women
- cardiovascular disease, lung disease, cancer, diabetes
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