Mechanisms Underlying Impaired Diabetic Wound Healing
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital, Diabetes |
| Therapuetic Areas: | Endocrinology, Other |
| Healthy: | No |
| Age Range: | 21 - 80 |
| Updated: | 4/4/2019 |
| Start Date: | September 2008 |
| End Date: | December 2020 |
| Contact: | Jennifer Mohnacky, RDN |
| Email: | jmohnack@iu.edu |
| Phone: | 317-278-2715 |
The overall aim of this research is to utilize wound derived inflammatory cells from diabetic
versus non diabetic human chronic wounds to understand mechanisms that are responsible for
disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood
derived cells) versus wound derived cells will also be studied.
versus non diabetic human chronic wounds to understand mechanisms that are responsible for
disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood
derived cells) versus wound derived cells will also be studied.
Specific aims:
1. To study biology of wound derived inflammatory cells and fluid from diabetic versus non
diabetic wounds.
2. To characterize mechanisms that are responsible for dysregulated wound inflammatory cell
function in individuals with diabetes.
3. To characterize differences in the biology of normal peripheral blood derived cells
versus wound derived cells.
The long-term goal of this study is to determine the molecular mechanisms underlying impaired
wound healing in diabetics.
1. To study biology of wound derived inflammatory cells and fluid from diabetic versus non
diabetic wounds.
2. To characterize mechanisms that are responsible for dysregulated wound inflammatory cell
function in individuals with diabetes.
3. To characterize differences in the biology of normal peripheral blood derived cells
versus wound derived cells.
The long-term goal of this study is to determine the molecular mechanisms underlying impaired
wound healing in diabetics.
Inclusion Criteria:
- Ages 21-80
- Chronic Wound (present >4 weeks)
- Diabetic & Non-diabetic
- Adult surgical wounds
Exclusion Criteria:
- Inability to consent
- Pregnant women
- Therapeutically immunocompromised
- Individuals defined in 45 CFR 46 Subparts B,C, and D, nor from any other population
considered vulnerable 2.9
We found this trial at
1
site
Indianapolis, Indiana 46202
Principal Investigator: Sashwati Roy, Ph.D
Phone: 317-278-2715
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