Using Neuroimaging to Investigate Major Depressive Disorder
| Status: | Completed |
|---|---|
| Conditions: | Anxiety, Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 2/8/2019 |
| Start Date: | May 2008 |
| End Date: | January 20, 2011 |
Using Neuroimaging to Investigate Neurobiological Correlates of Treatment Resistance Associated With Co-morbid Anxiety in Major Depressive Disorder
The purpose of this neuroimaging study is to investigate the brain correlates of Major
Depressive Disorder with anxiety symptoms as well as potentially identify predictors of
treatment outcome.
Depressive Disorder with anxiety symptoms as well as potentially identify predictors of
treatment outcome.
The purpose of this study is to test whether the structural and functional connectivity
between the dorso-lateral prefrontal cortex (DLPFC) and amygdala will decline as symptoms of
co-morbid anxiety (Anxiety Factor Score) increase in patients with MDD. This decrease in
connectivity will also account for decrease in treatment response. The structural
connectivity will be assessed using Diffusion Tensor Imaging (DTI) and the functional
connectivity will be assessed using resting state BOLD fMRI.We propose to use the fMRI and
DTI to identify biological markers that are associated with treatment response in a cohort of
patients with a spectrum of Anxiety Factor Scores.
between the dorso-lateral prefrontal cortex (DLPFC) and amygdala will decline as symptoms of
co-morbid anxiety (Anxiety Factor Score) increase in patients with MDD. This decrease in
connectivity will also account for decrease in treatment response. The structural
connectivity will be assessed using Diffusion Tensor Imaging (DTI) and the functional
connectivity will be assessed using resting state BOLD fMRI.We propose to use the fMRI and
DTI to identify biological markers that are associated with treatment response in a cohort of
patients with a spectrum of Anxiety Factor Scores.
Inclusion Criteria:
- Competent to give informed consent
- Diagnosis of Major Depressive Disorder
- Males and females
- Ages 18-50 years old
- All races and ethnicities
- Able to read, speak, and understand English*
Exclusion Criteria:
- History of psychiatric illness except Major Depressive Disorder, Generalized Anxiety
Disorder, Social Phobia, or Specific Phobia
- Alcohol or substance abuse within the last 6 months or alcohol or substance dependence
within the last year
- Diagnosis of an organic brain disease
- Serious unstable medical illness
- History of serious head injury
- Unsafe or unable to have an MRI or previous inability to tolerate MRI
- Pregnancy or breast feeding
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