Measurement of the Eye's Blood Vessels Using the Dynamic Vessel Analyzer (DVA)



Status:Archived
Conditions:Healthy Studies
Therapuetic Areas:Other
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:October 2008
End Date:December 2009

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Trial Summary
Trial Overview
Inclusion Criteria

Reproducibility of Dynamic Vessel Analyzer Measurements and Establishment of Standards


The purpose of this research study is examine the response of the blood vessels in the eye
to a light flicker stimulus using the Dynamic Vessel Analyzer (DVA) on two separate days in
healthy individuals. The DVA uses an instrument which is used during routine eye
examinations. The hypothesis of the study is that the changes in eye's blood vessel will be
similar between the two visits; thus establishing reproducibility of the measurements for
future comparisons to individuals with stroke or heart disease. In addition, this study will
compare the eye's blood vessel responses to responses of the blood vessels in the arm using
Doppler ultrasound.


Retinal blood vessels have been suggested to be an index of the cerebral and coronary
microvasculature function. Since the retinal vessels are not under direct sympathetic
control, this vascular bed is an ideal location to examine local mechanisms of vascular
regulation(i.e. metabolite/endothelial and myogenic). Based on previously published data on
animal and human responses, the central purpose for the proposed research is to compare the
retinal and brachial vasodilatation responses in healthy subjects using the Dynamic Vessel
Analyzer (DVA). Our rationale for this proposal is to better understand retinal blood flow
in healthy individuals, gain insight into vascular reactivity in different vascular beds,
and lastly to establish standards and reproducibility of DVA Measurements.


We found this trial at
1
site
Penn State Milton S. Hershey Medical Center
500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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mi
from
Hershey, PA
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