Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III

Inclusion Criteria:

- Age 18-80

- Symptom onset less than 24 hrs prior to diagnostic CT scan

- Spontaneous ICH less than or equal to 30 cc or primary IVH

- IVH obstructing 3rd and/or 4th ventricles

- ICH clot stability at 6 hours or more post IVC placement

- IVH clot stability at 6 hours or more post IVC placement

- Catheter tract bleeding stability 6 hours or more post IVC placement

- EVD placed per standard medical care

- SBP less than 200 mmHg sustained for 6 hours prior to drug administration

- Able to randomize within 72 hours of diagnostic CT scan

- Historical Rankin of 0 or 1

Exclusion Criteria:

- Suspected or untreated ruptured cerebral aneurysm, AVM, or tumor

- Presence of a choroid plexus vascular malformation or Moyamoya

- Clotting disorders

- Platelet count less than 100,000, INR greater than 1.4

- Pregnancy

- Infratentorial hemorrhage

- SAH at clinical presentation

- ICH/IVH enlargement that cannot be stabilized in the treatment time window

- Ongoing internal bleeding

- Superficial or surface bleeding

- Prior enrollment in the study

- Any other condition that the investigator believes would pose a significant hazard to
the subject if the investigational therapy were initiated

- Planned or simultaneous participation (between screening and Day-30) in another
interventional medical investigation or clinical trial.

- No subject or legal representative to give written informed consent