Use of Nitric Oxide Metabolites for Predicting Embryo Quality in In-Vitro Fertilization (IVF)
| Status: | Terminated |
|---|---|
| Conditions: | Women's Studies, Infertility |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 21 - 37 |
| Updated: | 12/13/2017 |
| Start Date: | January 2009 |
| End Date: | October 2009 |
Use of Nitric Oxide Metabolites for Predicting Embryo Quality in In-Vitro Fertilization
Improvements in In-Vitro Fertilization (IVF) outcomes have largely been due to the generation
of excess embryos allowing for multiple embryo transfer. Unfortunately this has also
increased the risk of multiple pregnancy with associated maternal and neonatal morbidity and
mortality. The investigators believe that the concentration of nitric oxide metabolites
measured in the culture medium from the first day of culture can identify the best quality
embryos allowing us to transfer a limited number of embryos without compromising the optimum
chance for pregnancy.
of excess embryos allowing for multiple embryo transfer. Unfortunately this has also
increased the risk of multiple pregnancy with associated maternal and neonatal morbidity and
mortality. The investigators believe that the concentration of nitric oxide metabolites
measured in the culture medium from the first day of culture can identify the best quality
embryos allowing us to transfer a limited number of embryos without compromising the optimum
chance for pregnancy.
Inclusion Criteria:
- Age 21-37
- Female
- Less than two previous unsuccessful IVF cycles
Exclusion Criteria:
- Day 3 FSH >9.9
- Fewer than 8 mature oocytes retrieved
- Fewer than 8 normally fertilized embryos on day 2 after fertilization
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