Reversal of Hypoglycemia Unawareness Using Continuous Glucose Monitoring

To enroll in this study you must be between the ages of 7 and 20, have type 1 diabetes, and
experience at least two episodes of low blood glucose readings weekly that you do not feel.
Up to 25 subjects will be enrolled at Stanford and another 25 at the Barbara Davis Center in
Colorado. The study will last approximately 8 months for each participant.

Inclusion Criteria:

1. Be at least 7 to 20 years old

2. Have been diagnosed with type 1 diabetes for at least 1 year

3. Report 2 or more episodes per week of asymptomatic hypoglycemia as determined by
completion of the Hypoglycemia Awareness Questionnaire (HAQ) or as determined by
Investigator

4. HbA1c level < 10%

5. Internet access for downloading continuous glucose monitoring (CGM), access to a
compatible computer (Windows Vista is not compatible for downloading.)

6. For females, you are not intending to become pregnant during the study

7. No expectation that you will be moving out of the area for the duration of the study

Exclusion Criteria:

1. The presence of a significant medical disorder (including epilepsy, or any cause of
seizures other than hypoglycemia) that in the judgment of the Investigator will affect
the wearing of the sensors or the completion of any aspect of the protocol

2. Treatment with systemic or inhaled corticosteroids in the last six months

3. Inpatient psychiatric treatment in the past six months for you or your primary
caregiver

4. Current use of oral/inhaled glucocorticoids or other medications, which in the
judgment of the Investigator would be a contraindication to participation in the study

5. Having two or more severe hypoglycemia episodes (seizure or loss of consciousness) in
the six months prior to enrollment

6. Having a severe hypoglycemic episode in the 30 days prior to enrollment