WiiMote Game Controller as a Device to Study Movement Disorders

The expected length of taking part in this study will depend on whether or not subjects are
chosen for a group to look at the reproducibility of the data collected from the Wii remote.
If subjects agree to take part in the study, basic data including age, gender, ethnicity,
and medications will be collected. If subjects have been diagnosed with a movement disorder,
that diagnosis will also be recorded. This data will be secured in a HIPAA compliant
computer system and recorded data will be given a unique random code. During the Wii remote
portion of the study, subjects will be asked to hold the Wii remote controller in several
different positions and perform various movements with the controller.

These include:

1. Holding the controller still with the elbow straight and then the elbow bent.

2. Tapping the control button as fast as you can.

3. Rotation of your wrist as fast as you can.

4. Bending at the wrist and at the elbow as fast as you can.

5. Walking 30 feet.

6. Attaching the controller to your arm with a Velcro strap and repeating the motions
performed while holding the controller.

These maneuvers will be done first with the right and then the left hand. We expect that
this series will take about 5 minutes.

If subjects have Parkinson's disease they will also be asked to undergo Part III (Motor
Sub-Scale) of the Unified Parkinson's Disease Rating Scale. This scale measures various
aspects such as finger tapping, hand opening and closing and walking on a scale of 0 - 4. We
expect that this portion of the examination will take about 5 minutes.

If subjects carry the diagnosis of Essential Tremor, they will be asked to undergo Standard
Measure of EssentialTremor that includes drawing of spirals and pouring of water from one
glass to another. Again, we estimate that this scale will take about 5 minutes.

If subjects carry the diagnosis of Parkinson's disease or Essential Tremor and have deep
brain stimulation surgery, results of using the Wii™ Remote game controller (handheld or
attached using a Velcro strap) will be done during a clinical programming appointment. The
information obtained will not be used for any clinical use and will not interfere with the
normal standard of care.

A sub-set of patients will be asked to repeat these measures at various times to see if
there is either a learning curve, or if the measures are repeatable over time. Subjects may
decline this at any point in time.

Inclusion Criteria:

1. Men and women, aged 18 or older, with abnormal movements (including tremor, chorea,
dystonia, myoclonus, and tic) and normal controls (subjects without abnormal
movements).

2. Subjects must be willing and able to comply with study procedures.

3. Patients must be willing and able to give meaningful, written informed consent.

Exclusion Criteria:

1. Significant cognitive impairment which, in the opinion of the Investigator, would
interfere with the ability to complete all the tests required in the protocol.