The Expression and Significance of MiRNA
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | July 2008 |
| End Date: | December 2015 |
| Contact: | Janice E. Drake, CRRT |
| Email: | janice.drake@osumc.edu |
| Phone: | 614-366-2287 |
The Expression and Significance of miRNA Profile and Markers of Inflammation in Patients With Pulmonary Arterial Hypertension
It is not always known what causes PAH or what the best treatment is. The doctors doing this
study would like to understand more about why some people develop PAH and other do not. They
also would like to learn more about which treatments might help PAH and which people might
respond better to treatments.
Doctors think that testing certain substances found in blood cells might help answer these
questions. These substances are normally released by our bodies to protect us from infection
and to tell the difference between normal and foreign substances in our body. Finally, a new
test will study very small molecules called microRNA that control how our genes are
expressed. This study is being done to see if blood samples can be tested to determine who
might develop PAH, how well drugs will work to treat PAH and to learn more about the
development of PAH.
study would like to understand more about why some people develop PAH and other do not. They
also would like to learn more about which treatments might help PAH and which people might
respond better to treatments.
Doctors think that testing certain substances found in blood cells might help answer these
questions. These substances are normally released by our bodies to protect us from infection
and to tell the difference between normal and foreign substances in our body. Finally, a new
test will study very small molecules called microRNA that control how our genes are
expressed. This study is being done to see if blood samples can be tested to determine who
might develop PAH, how well drugs will work to treat PAH and to learn more about the
development of PAH.
You will be asked to donate blood when you have your right heart catheterization and also at
the 3-4 month follow-up visit. The amount of blood collected during your heart
catheterization is about 20cc (about 4 teaspoons). This blood is discarded as part of the
clinical catheterization procedure, but we are asking that we use it for this research
study. Then, at the follow-up right heart catheterization, you will be asked to donate 20 cc
(which is about 4 teaspoons) of blood.
If the second right heart is not required for clinical purposes then you will be asked to
give a blood sample during your 3-4 month follow up clinic visit.
If you require an additional right heart catheterization, within one year, we will ask that
you donate additional samples at the subsequent RHC.
Other data collected as part of your clinical care, such as medical history, chest x-ray
(picture of your lungs), echocardiogram (picture of your heart), ventilation perfusion scan
(determines how much blood goes to your lungs), chest CT (thin pictures of my lungs as
slices), pulmonary function tests (breathing tests), and lab blood tests, will be used as
part of this research.
the 3-4 month follow-up visit. The amount of blood collected during your heart
catheterization is about 20cc (about 4 teaspoons). This blood is discarded as part of the
clinical catheterization procedure, but we are asking that we use it for this research
study. Then, at the follow-up right heart catheterization, you will be asked to donate 20 cc
(which is about 4 teaspoons) of blood.
If the second right heart is not required for clinical purposes then you will be asked to
give a blood sample during your 3-4 month follow up clinic visit.
If you require an additional right heart catheterization, within one year, we will ask that
you donate additional samples at the subsequent RHC.
Other data collected as part of your clinical care, such as medical history, chest x-ray
(picture of your lungs), echocardiogram (picture of your heart), ventilation perfusion scan
(determines how much blood goes to your lungs), chest CT (thin pictures of my lungs as
slices), pulmonary function tests (breathing tests), and lab blood tests, will be used as
part of this research.
Inclusion Criteria:
- ≥ 18 years of age
- Not pregnant
- Undergoing right heart catheterization for PAH diagnosis
Exclusion Criteria:
- Pregnant
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