Girls OnGuard: HPV Vaccination Uptake Among African American Adolescent Females

African American adolescent females seeking treatment for STIs are an underserved population
at increased risk for HPV infection. While GARDASIL is an effective preventive vaccine,
vaccination rates are low. Given the risk for HPV infection among this subgroup and the
negative health effects associated with HPV, enhancing uptake of GARDASIL is necessary. The
goal of this project is to promote GARDASIL vaccination through the development of a new
multi-component, culturally-appropriate, interactive DVD.

We propose to recruit 280 unmarried African American adolescent females, 13-18 years of age,
from participating clinic sites in Atlanta, Georgia. While seeking clinical services,
adolescents will be contacted and invited to participate in the proposed study. Eligible
adolescents will be required to provide written assent/consent prior to participation.
Adolescents who are eligible and willing to participate in the project will complete a short
survey on a laptop computer. The survey is designed to assess adolescents' risk taking and
preventive behaviors. After they complete the survey, adolescents will be assigned at
random to one of two groups. In one group, adolescents will watch a short (10 min),
interactive DVD designed to promote HPV awareness and initial GARDASIL vaccination and
receive a keepsake to help them remember to return to the clinic for their second and third
vaccine doses. In the second group, adolescents will watch an equally short (10 min) DVD on
healthy lifestyles and behaviors. All adolescents are eligible to receive the GARDASIL
vaccine at participating study clinics as part of their routine standard of care.

With the help of clinic staff, participant medical records will be reviewed over a 7 month
period to assess vaccination rates. Vaccination rates from adolescents who received the
interactive HPV/GARDASIL awareness DVD will be compared to the group of adolescents who
received the healthy lifestyles DVD. It is hypothesized that study participants receiving
the interactive DVD intervention that promotes HPV awareness will have higher vaccination
rates over time.