Prevention and Treatment of Immersion Pulmonary Edema
| Status: | Completed |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 4/21/2016 |
| Start Date: | January 2008 |
| End Date: | December 2015 |
Effects of the Dive Reflex on Pulmonary Arterial and Pulmonary Artery Wedge Pressures in Subjects Who Have Experienced Immersion Pulmonary Edema
Immersion pulmonary edema (IPE) is a condition in which fluid fills the lungs during diving
or swimming, particularly in cold water. Some individuals appear to be predisposed to
developing IPE. DNA samples will be collected and stored, in order to compare the genetic
profiles of individuals who have experienced IPE with those who have not. In a few
individuals who have experienced IPE, we plan to measure the effects of cold water immersion
on the blood pressure, cardiac output and the pressures in the pulmonary artery. These will
be compared with similar measurements already obtained from normal individuals.
or swimming, particularly in cold water. Some individuals appear to be predisposed to
developing IPE. DNA samples will be collected and stored, in order to compare the genetic
profiles of individuals who have experienced IPE with those who have not. In a few
individuals who have experienced IPE, we plan to measure the effects of cold water immersion
on the blood pressure, cardiac output and the pressures in the pulmonary artery. These will
be compared with similar measurements already obtained from normal individuals.
Immersion pulmonary edema (IPE) is a condition that has sudden onset in swimmers and divers,
and is characterized by cough, shortness of breath, decreased blood oxygen levels, and
hemoptysis. The purpose of this study is to examine the effects of cold water immersion and
the dive reflex on pulmonary arterial pressure and pulmonary capillary wedge pressure in
those who have already experienced IPE, as well as explore the possibility of a genetic
predisposition. Healthy nonsmoking subjects who have experienced IPE will be recruited for
several cold-water immersion experiments and DNA analysis. Their pulmonary arterial and
pulmonary arterial wedge pressures will be measured as they undergo immersed rest and
exercise trials in thermoneutral and cold water. If the pressures increase with these trials
as hypothesized, the effects of sildenafil administration (a pulmonary vasodilator) will be
tested during a second trial. Blood will also be drawn for DNA analysis of certain genes
with possible relation to IPE. Results of these tests will be compared with those of the
general population.
and is characterized by cough, shortness of breath, decreased blood oxygen levels, and
hemoptysis. The purpose of this study is to examine the effects of cold water immersion and
the dive reflex on pulmonary arterial pressure and pulmonary capillary wedge pressure in
those who have already experienced IPE, as well as explore the possibility of a genetic
predisposition. Healthy nonsmoking subjects who have experienced IPE will be recruited for
several cold-water immersion experiments and DNA analysis. Their pulmonary arterial and
pulmonary arterial wedge pressures will be measured as they undergo immersed rest and
exercise trials in thermoneutral and cold water. If the pressures increase with these trials
as hypothesized, the effects of sildenafil administration (a pulmonary vasodilator) will be
tested during a second trial. Blood will also be drawn for DNA analysis of certain genes
with possible relation to IPE. Results of these tests will be compared with those of the
general population.
Inclusion Criteria:
- History of immersion pulmonary edema
Exclusion Criteria:
- Coronary artery disease, cardiomyopathy, heart valve disease
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