Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)
| Status: | Completed |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/30/2013 |
| Start Date: | January 2009 |
| End Date: | June 2011 |
| Contact: | Nathalie L Maitre, MD, PhD |
| Email: | nathalie.maitre@vanderbilt.edu |
| Phone: | 615 322 4943 |
Influence of Altered Cerebral Spinal Fluid and Arterial Flows on Cerebral Processing Functions in Premature Infants With Severe Intraventricular Hemorrhage
Currently, when premature infants develop severe intraventricular hemorrhage (IVH), a type
of intracerebral bleed, there are no proven therapeutic interventions to prevent the
devastating consequences of this event. These children will be likely to develop cerebral
palsy or severe cognitive delays.
The purpose of our study is to characterize differences in brain physiology, imaging, and
function between premature infants with severe IVH and controls. The goals for gathering
this information are to generate baseline data, which could facilitate early screening for
complications of IVH in premature infants. These baseline data would also allow the design
and implementation of early therapeutic interventions to help rehabilitate premature infants
with severe IVH.
Inclusion Criteria:
- Birth weight < 1500 grams for all inborn infants and age less than 14 post-natal days
- Birth weight < 1500 grams for all outborn infants transferred to the VCH NICU within
the first 72 hours after birth and age less than 14 post-natal days
- Parents agree to their infant's participation and give informed written consent.
Exclusion Criteria:
- Unable to obtain informed consent.
- Congenital brain malformations leading to hydrocephalus
- Genetic and metabolic disorders leading to cerebral pathology
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