Early Parkinson's Disease (PD) Cross-Sectional

Purpose:

1. To see if cytokine levels and oligomeric alpha-synuclein levels in blood and
cerebrospinal fluid could be used as biological markers for Parkinson's disease (PD)
onset and progression.

2. To characterize and define patterns in the clinical features of sleep, olfactory
function and motor function in the early stages of idiopathic (sporadic) Parkinson's
disease (PD)and atypical or late Parkinsonian Syndromes.

Procedures:

All subjects, control,early PD diagnosis and atypical or late Parkinsonian Syndromes, will
have 1) a medical and neuro history and physical including videotaping of movements, 2)
neuropsychological testing, 3) a sleep study, 4) olfactory (sense of smell) testing, 5)blood
draw and LP for serum and CSF testing, & 6) functional MRI. All of these procedures are
often done in the diagnosis of PD. Any test performed prior to enrollment as part of the
clinical evaluation may be used in place of repeating the procedure. Subjects will have 1
set of study visits (up to 3 visits) in order to accomplish a complete set of data.