A Proof of Concept Study to Evaluate the Effectiveness of Tysabri in Relapsing Remitting Multiple Sclerosis (RRMS) Patient Bladder Function

A recent report has demonstrated improvements in QoL parameters in patients receiving
TYSABRI® (Rudick et al, 2007). This observation, coupled with anecdotal reports and our own
experience, lead us to hypothesize that TYSABRI® will have a demonstrable beneficial effect
on improving patient's bladder function as defined by changes in baseline to month 6 scores
on the UDI-6 and also on patient reported incontinence episodes and micturitions per day.