Phenytoin and Multidose Activated Charcoal
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/30/-0001 |
| Start Date: | August 2008 |
| Contact: | Carl Skinner, MD |
| Email: | cskinne@emory.edu |
| Phone: | 404-230-8953 |
Prospective Randomized Study of Multidose Activated Charcoal in Supratherapeutic Phenytoin Serum Levels
Phenytoin is a medicine used to treat seizures. If too much is taken, patients have ill
effects including sleepiness, unsteady gait, and eye problems. The amount of drug in their
system can be measured in their blood. Charcoal is a medicine that can absorb phenytoin. We
want to see if giving multiple doses of charcoal will quicken the removal of phenytoin from
the blood. This is theorized to occur as charcoal absorbs phenytoin from across the
intestines and then is secreted in the stool. Patients will be selected to receive either
charcoal in multiple doses or no charcoal and their serum levels will be drawn repeatedly to
follow their level. The different groups will then be compared to see if multidose charcoal
does indeed shorten the half-life of phenytoin in the blood.
Inclusion Criteria:
- Phenytoin level > 30 mg/L
Exclusion Criteria:
- Age < 18 Known allergy to Activated Charcoal Pregnant Inability to take PO drugs Non
English speaking Inability to give consent Any prisoners
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