Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes
| Status: | Completed |
|---|---|
| Conditions: | Cognitive Studies, Neurology |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/2/2017 |
| Start Date: | June 2009 |
| End Date: | July 2012 |
This study offers 90-120 hours of 1:1 training to improve reading skills in adults who have
poor reading skills following a stroke. Specifically, this study is designed to improve skill
in sounding out words for reading and spelling. The overall time commitment for participation
in this study is approximately 11-30 weeks.
poor reading skills following a stroke. Specifically, this study is designed to improve skill
in sounding out words for reading and spelling. The overall time commitment for participation
in this study is approximately 11-30 weeks.
The proposed study is a mixed-effects (single-subject ABA repeated-probe and small group
elements) design with 90-120 hours of a modified multi-modal treatment of alexia replicated
across up to 18 adults with post-stroke phonological alexia. The short-term goals of this
research proposal includes the following: 1) determine if a modified multimodal treatment of
phonological alexia can improve pseudoword reading skills (providing a basis from which
training will also treat real word reading skills), 2) determine if a modified multimodal
treatment of phonological alexia can improve real word reading skills, 3) determine how brain
lesion extent and location relate to participants' response to treatment, and 4) identify
relationships between changes in functional brain activity in specified regions of interest
and participants' response to treatment.
elements) design with 90-120 hours of a modified multi-modal treatment of alexia replicated
across up to 18 adults with post-stroke phonological alexia. The short-term goals of this
research proposal includes the following: 1) determine if a modified multimodal treatment of
phonological alexia can improve pseudoword reading skills (providing a basis from which
training will also treat real word reading skills), 2) determine if a modified multimodal
treatment of phonological alexia can improve real word reading skills, 3) determine how brain
lesion extent and location relate to participants' response to treatment, and 4) identify
relationships between changes in functional brain activity in specified regions of interest
and participants' response to treatment.
Inclusion Criteria:
- Adults with post-stroke reading difficulties (phonological alexia)
- >3 months post-stroke
- native English speaker
- can go in MRI scanner (3 to 6 scans),
- participate in 90 to 120 free treatment sessions
- return for 3-month post-treatment follow-up assessment & MRI.
Exclusion Criteria:
- mental illness
- degenerative disease, visual or auditory acuity impairment
- drug abuse
- English is not first language
- claustrophobia
- pregnancy
We found this trial at
1
site
Click here to add this to my saved trials
