Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | April 2006 |
| End Date: | December 2012 |
| Contact: | Rachel Burrows, BA |
| Email: | rburrows@dom.wustl.edu |
| Phone: | 314-747-2627 |
VLDL-triglyceride Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
This study is being conducted to learn more about the role of diet and exercise in
regulating plasma triglyceride (fat) metabolism. The investigators will examine the effect
of acute (24 hour) changes in energy intake and expenditure on fat metabolism the following
day.
Excess body fat and a sedentary lifestyle are associated with increased plasma triglyceride
(TG) and apolipoprotein B-100 (apoB-100) concentrations, which are important risk factors
for the development of cardiovascular disease.
Weight loss and endurance exercise improve plasma lipid and lipoprotein concentrations.
However, the mechanisms responsible for this effect are largely unknown, and much
uncertainty remains regarding the independent roles of dietary energy intake, exercise
energy expenditure, and net energy balance in controlling plasma TG concentrations.
The main goal of this project, therefore, is to investigate the mechanisms by which acute
alterations in energy balance, induced by diet and/or physical activity (endurance
exercise), regulate very-low density lipoprotein (VLDL) metabolism.
Inclusion Criteria:
- overweight and obese men
- normal to mild hypertriglyceridemia
Exclusion Criteria:
- Smoking
- Any medical condition other than increased body weight (e.g. diabetes, heart disease,
etc.).
- Use of drugs known to affect lipid metabolism (e.g. statins, etc.).
- Regular exercise training.
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