Endothelial Function and Vein Graft Remodeling
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 22 - 89 |
| Updated: | 4/21/2016 |
| Start Date: | January 2009 |
| End Date: | December 2017 |
| Contact: | Diana Kim, M.P.H. |
| Phone: | 415-353-4366 |
The purpose of this study is to better understand why some vein bypass grafts develop
narrowing. Evidence suggests that there is a relationship between inflammatory markers in
the blood and the narrowing that occurs in blood vessels. In this study, we will look at
inflammatory markers in the blood and how well the vein graft functions.
narrowing. Evidence suggests that there is a relationship between inflammatory markers in
the blood and the narrowing that occurs in blood vessels. In this study, we will look at
inflammatory markers in the blood and how well the vein graft functions.
Inclusion Criteria:
- Age > 22 or < 90 years
- Undergoing lower extremity (infrainguinal) bypass using autologous vein for the
treatment of disabling claudication or critical limb ischemia secondary to chronic
atherosclerotic occlusive disease
- Able to understand, give, and take part in the consent process
Exclusion Criteria:
- Age < 22 or > 90 years
- Grafts employing prosthetic or other non-autologous vein material in any part (e.g.
composite grafts). [Patch angioplasty of inflow and outflow vessel permissible with
any material]
- Vasculitis, trauma, acute embolic disease as etiology of limb ischemia
- History of diagnosed hypercoagulable state
- Evidence of active infection - pneumonia, urinary tract, etc., requiring medical
therapy
- Evidence of significant local sepsis in foot or limb prior to bypass
- Patients taking immunosuppressant medications (steroids, chemotherapeutic agents)
- Other concurrent significant illness within 30 days
- Non-English speakers
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2
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