Study of Cicletanine for Pulmonary Arterial Hypertension (PAH)
| Status: | Archived |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | January 2009 |
| End Date: | December 2015 |
A Phase 2, Randomized, Double-blind, Placebo-controlled, Multicenter, Dose-ranging Study of Cicletanine in Subjects With Pulmonary Arterial Hypertension
This Phase 2, randomized, double-blind, placebo-controlled, multicenter, dose-ranging study
will compare the efficacy, safety, and tolerability of cicletanine HCl to placebo in
subjects with PAH. Study drug will be administered alone, or on the background of stable PAH
therapy. The study will consist of 3 periods: a screening period, a 12-week
placebo-controlled treatment period, and a long-term, blinded extension period.
The primary objective of this study is to compare the change in exercise capacity following
treatment with cicletanine HCl or placebo in subjects with PAH.
The secondary objectives of this study are:
1. To compare the change in other clinical measures of PAH following treatment with
cicletanine HCl or placebo in subjects with PAH
2. To compare the safety and tolerability of cicletanine HCl to placebo in subjects with
PAH Additionally, the long-term safety, tolerability, and efficacy of cicletanine HCl
treatment will be evaluated.
We found this trial at
40
sites
Children's Hospital - Boston Boston Children's Hospital is a 395-bed comprehensive center for pediatric health...
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Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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University of Maryland, Baltimore Welcome to the University of Maryland, Baltimore (UMB) founded in 1807...
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Boston Med Center Boston Medical Center (BMC) is a 496-bed academic medical center located in...
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Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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University of Chicago One of the world's premier academic and research institutions, the University of...
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5303 Harry Hines Boulevard
Dallas, Texas 75390
Dallas, Texas 75390
(214) 648-3111
UT Soutwestern Medical Center at Dallas UT Southwestern Medical Center is distinctive for its overall...
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University of Florida Gainesville UF has a long history of established programs in international education,...
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University of Iowa With just over 30,000 students, the University of Iowa is one of...
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Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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3400 Spruce St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Washington University Washington University creates an environment to encourage and support an ethos of wide-ranging...
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Cleveland Clinic Florida Cleveland Clinic Florida, located in Weston, West Palm Beach, Palm Beach Gardens...
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Med College of Georgia Georgia Regents University, home of the Medical College of Georgia, is...
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University of Colorado, Boulder As the flagship university of the state of Colorado, CU-Boulder is...
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101 Manning Dr
Chapel Hill, North Carolina 27599
Chapel Hill, North Carolina 27599
(919) 966-4131
University of North Carolina Hospital at Chapel Hill The UNC Health Care System is a...
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University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
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Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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263 Farmington Ave
Farmington, Connecticut 06030
Farmington, Connecticut 06030
(860) 679-2000
University of Connecticut Health Center UConn Health is a vibrant, integrated academic medical center that...
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Baylor School of Medicine Baylor College of Medicine is a health sciences university that creates...
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UCLA Medical Center Founded in 1955, UCLA Medical Center became Ronald Reagan UCLA Medical Center...
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University of South Alabama "University of South Alabama is a public institution that was founded...
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Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
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Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
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Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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601 Elmwood Ave
Rochester, New York 14642
Rochester, New York 14642
(585) 275-2100
Strong Memorial Hospital (University of Rochester School of Medicine) In addition to offering traditional and...
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