[18F] FACBC and [18F] FLT PET Imaging in Central Nervous System Tumors
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/29/2018 |
| Start Date: | January 2009 |
| End Date: | March 21, 2017 |
18F] FACBC and [18F] FLT PET Imaging in Central Nervous System Tumors
The purpose of this study is to help us understand gliomas, one type of brain tumor. This
research protocol makes pictures of gliomas. We will take pictures of the glioma before and
after treatment. The pictures are made with a positron emission tomography (PET) scanner. PET
scans use radioactive markers to "see" cancer cells. We plan to use two different radioactive
markers, [18F]FACBC and [18F]FLT, to "see" if the glioma responds to the treatment being
recommended by the doctor. We are investigating whether one or both of these types of PET
scans can help us to better understand gliomas and their response to treatment.
We expect these pictures will give us information the your tumor and may help us to
understand why the treatment that the patient is receiving is affecting the tumor the way
that it is. We also hope to collect information about the amount of radioactivity exposure.
We will measure radioactivity exposure to the tumor, brain and other organs.
research protocol makes pictures of gliomas. We will take pictures of the glioma before and
after treatment. The pictures are made with a positron emission tomography (PET) scanner. PET
scans use radioactive markers to "see" cancer cells. We plan to use two different radioactive
markers, [18F]FACBC and [18F]FLT, to "see" if the glioma responds to the treatment being
recommended by the doctor. We are investigating whether one or both of these types of PET
scans can help us to better understand gliomas and their response to treatment.
We expect these pictures will give us information the your tumor and may help us to
understand why the treatment that the patient is receiving is affecting the tumor the way
that it is. We also hope to collect information about the amount of radioactivity exposure.
We will measure radioactivity exposure to the tumor, brain and other organs.
Inclusion Criteria:
- Registered patient at MSKCC.
- Child-bearing age females must be non-pregnant,(documented by a negative pregnancy
test within the last 2 weeks), non-lactating, and must be using adequate contraception
or be surgically sterile.
- Patients with gliomas
- Patients planning to start anti-AKT and/or anti-VEGF directed therapies .
- Patients with measurable disease on MRI or CT neuroimaging.
Exclusion Criteria:
- Patient is incontinent of urine or stool (which would make them unable to tolerate
lying still for 60 minutes).
- Patient cannot tolerate lying still for a 60 minute session in the PET tomograph.
We found this trial at
1
site
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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