A Natural History Study of Patients With Dry Eye

Inclusion Criteria:

- Males at least 55 years old or females, at least 40 years old with perimenopausal
symptoms

- Baseline OSDI score of ≥ 13

- Patients with mild to moderate dry eye (dry eye disease patients only; not applicable
for control group)

Exclusion Criteria:

- Use of any topical cyclosporine ophthalmic emulsion within 3 months of baseline

- History of herpes keratitis or varicella zoster keratitis

- Any history of allergic conjunctivitis

- Temporary or permanent occlusion or cauterization of the lacrimal puncta for either
eye

- Any anterior segment surgery involving a limbal or corneal incision (cataract
surgery), keratorefractive procedure (LASIK, LASEK, PRK) within 12 months of
baseline, or expectation of such surgery within 2 years

- Patients with known systemic disease

- Any history of corneal transplant