Evaluation of the Cardioblate Closure Device in Facilitating Occlusion of the Left Atrial Appendage

Inclusion Criteria:

- Subject is greater than or equal to 18 years of age and less than or equal to 80
years of age

- Concomitant indication for cardiac surgery for one or more of the following:mitral
valve repair or replacement, aortic valve repair or replacement, tricuspid valve
repair or replacement CABG (>=60 years of age), CABG (< 60 years of age with a
history of atrial fibrillation), surgical ablation or Maze procedure

- The subject is willing and able to provide written informed consent and comply with
study requirements

- The subject is not contra-indicated for intra-operative transesophageal
echocardiogram (TEE)

Exclusion Criteria:

- Thrombus in the LAA and/or left atrium

- Prior LAA isolation attempts

- Subject is unable to take an anticoagulant during the study follow-up period

- Subject is undergoing an emergency cardiac procedure

- Life expectancy of less than 12 months

- Pregnancy or desire to be pregnant within the 12 months of the study procedure