Immunological Characterization of Bronchoalveolar Cells in Normals
| Status: | Archived |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | March 1978 |
| End Date: | February 2012 |
To obtain the monocytes (white blood cells) from normal volunteers for the purpose of
studying how proteins, fats, carbohydrates, as well as RNA and DNA for gene expression,
relate to immunity. This information will be compared to other studies in patients with
lung diseases such as Emphysema, Sarcoidosis, and Interstitial Pulmonary Fibrosis.
To determine the functional capabilities of cells obtained from bronchoalveolar lavage fluid
and peripheral blood monocytes from normal individuals. The ongoing objective varies from
investigation to investigation but in general the investigational goals are to better
understand the immune function of monocytes purified from normal volunteers. In some
instances the emphasis will be upon comparing the specific immune function (e.g. ability to
sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar
macrophages. This comparison is not the only goal of the study, however. In many cases the
immune function of the monocyte will be sufficient in and of itself as an investigational
goal. In other cases the same is true of alveolar macrophage function.
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