Electrocardiographic Autonomic Function Measures in Mechanically Ventilated Patients

This research proposal has two main objectives. The first is to increase understanding of
the underlying physiological interactions that occur between the cardiovascular, pulmonary,
and ANS during transition between positive pressure mechanical ventilation (MV) and
spontaneous breathing. The second is to determine if heart rate variability, (HRV) a
reflection of autonomic nervous system (ANS) activity, and autonomic information flow (AIF),
a set of nonlinear measures derived from HRV, both measured in the intensive care unit (ICU)
can predict patient outcomes including successful weaning and in-hospital recovery time
after an episode of cardiopulmonary compromise requiring MV.

Hypothesis 1. Transitions between mechanically supported ventilation and spontaneous
breathing will disturb cardiovascular synchrony, altering the relationship of HRV, AIF,
respiratory rate, and blood pressure;

Hypothesis 2. More normal HRV and AIF values, measured during baseline MV and sedation
awakening (a period immediately prior to SBT when sedative medications are discontinued)
will be associated with easier weaning, and shorter intensive care unit (ICU) and hospital
lengths of stay; more abnormal measurements will be associated with longer lengths of stay;

Hypothesis 3. AIF is a more sensitive predictor of successful weaning from MV than HRV.