Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder, Depressed Type: Prevalence and Improvement With Treatment of Depressive Symptoms
| Status: | Completed |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD), Psychiatric, Bipolar Disorder |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/23/2013 |
| Start Date: | December 2007 |
| End Date: | December 2012 |
| Contact: | John D. Matthews, MD |
| Email: | jmatthews@partners.org |
| Phone: | 617-724-9144 |
Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder Depressed Type: Prevalence and Symptoms With Treating of Depressive Symptoms
The purpose of this research study is to learn more about cognitive deficits in people with
certain mood disorders. The mood disorders are Major Depressive Disorder (MDD) and Bipolar
disorder, depressed type.
Cognitive deficits are problems with things like thinking and memory. People with cognitive
deficits may have problems concentrating and paying attention. When talking, they may have
trouble recalling a word they want to say. They may think slowly and have problems
remembering things. These deficits can affect an individual's ability to work and function
socially. Cognitive deficits that occur with depression may increase the risk of a relapse
of major depressive disorder.
We want to study the course of cognitive impairment in subjects as they are receiving
treatment for their depression. We want to find out if their cognitive deficits get better,
worse, or stay the same.
We also want to learn more about a stress hormone called cortisol that is produced in the
body. We want to study the relationship between cortisol and cognitive impairment. Recent
research has shown that cognitive impairment may be more severe in people who have high
levels of cortisol in their blood.
We will also measure the levels of a protein in your blood called brain-derived neurotrophic
factor (BDNF). BDNF helps the growth of new brain cells. It appears that the growth of new
brain cells lessens when people are depressed. Treatment with antidepressant medications
may cause BDNF levels to increase and return to normal. We are interested in studying the
relationship between BDNF levels and cognitive impairment throughout treatment.
Inclusion Criteria:
1. Eligible subjects will be inpatients admitted to the Massachusetts General
Psychiatric inpatient service, Blake 11 with diagnoses of MDD with and without
psychotic features and BPDD with and without psychotic features.
2. Subjects will include men and women aged 18-85.
3. Competent to give informed consent.
Exclusion Criteria:
1. Patients with illnesses that impair cognitive functioning including: vascular
dementia, and neurological illnesses including Parkinson's Disease, Huntington's
Disease, multiple sclerosis, and Alzheimer's Disease.
2. The following DSM-IV diagnoses: schizophrenia, schizoaffective disorder, delusional
disorder, organic mental disorder, substance use disorders including alcohol, active
within the past 6 months, acute bereavement, and psychotic disorder not elsewhere
classified.
3. Pregnant women
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