Postprandial Endothelial Dysfunction After a High-Fat Meal in HIV-infected Men



Status:Completed
Conditions:Peripheral Vascular Disease, Infectious Disease, HIV / AIDS
Therapuetic Areas:Cardiology / Vascular Diseases, Immunology / Infectious Diseases
Healthy:No
Age Range:18 - Any
Updated:10/14/2017
Start Date:January 2008
End Date:January 2010

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to examine the postprandial (anytime after a meal) effect of
different dietary fats on endothelial function in HIV-infected and HIV-uninfected men.

This study requires two visits. Once determined eligible by the study criteria, during the
first visit the participant will be randomly placed to receive one of two high-fat meals. The
participant will receive the other study meal during the second visit. At each visit,
brachial artery ultrasounds will be performed before and 3 hours after the meal is eaten. The
sample size is 50 subjects. This study will be conducted at the Clinical Research Center at
Tufts Medical Center.

Inclusion Criteria:

- HIV-positive white male aged >18 years

- Under one of the following treatment categories:

- Treatment naive or have never taken any HIV medications

- Taking Kaletra

- Taking Sustiva

- Taking Atripla

Exclusion Criteria:

- Smoker

- Pre-existing diagnosis or treatment for the following:

- Lipid disorder

- Cardiovascular disease

- High blood pressure

- Diabetes

- Acute opportunistic infection or malignancy within last 3 months or current therapy
for either

- Active IV drug use
We found this trial at
1
site
Tufts University
Boston, Massachusetts 02111
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mi
from
Boston, MA
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