Quality of Life in Patients With Statin-Associated Myopathy

The proposed study will focus on possible effects of statins on muscle strength and why they
become tired more easily, quality of life, and measurements to understand why muscles are
not able to fully utilize fats. The investigators are specifically interested in statin
users and the impact of muscle symptoms on daily activities and quality of life.

This study hypothesize that patients with likely statin-associated myopathy have a metabolic
dysregulation in fuel utilization such that compared to patients continuing statins, those
on placebo will show:

1. improved INQoL and SF-36 scores (primary end point)

2. alleviation of muscle symptoms,

3. increased utilization of fatty acids as a fuel source reflected by the metabolic test
results

4. decreased IMCL

5. improved insulin sensitivity.