Role of Bone in Knee Osteoarthritis (OA)
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/28/2015 |
| Start Date: | July 2008 |
| End Date: | December 2012 |
| Contact: | Aaron Yengo-Kahn, BS |
| Email: | ayengok@caregroup.harvard.edu |
| Phone: | 617-754-6697 |
The Role of Bone and Its Measurement in Knee Osteoarthritis
The purpose of the study is to investigate protein and gene expression among damaged knee
tissues. We will perform MRI's on subjects prior to total knee replacement to identify the
location of bone marrow lesions. Connective tissues including tendon, ligament, and meniscus
specimens normally discarded from total joint replacements will be used for live cell
harvest, and protein and gene expression analyses of tissue or cultured cells.
tissues. We will perform MRI's on subjects prior to total knee replacement to identify the
location of bone marrow lesions. Connective tissues including tendon, ligament, and meniscus
specimens normally discarded from total joint replacements will be used for live cell
harvest, and protein and gene expression analyses of tissue or cultured cells.
BACKGROUND AND SIGNIFICANCE:
Although the presence of bone marrow lesions (BML) on MRI is strongly associated with
osteoarthritis (OA) progression and pain in some studies, the mechanism for this relation
and the underlying pathology is not well established. The lack of knowledge on what these
lesions constitute hampers their clinical utility both with regards to measurement and
targeting for therapeutic intervention.
Our preliminary data has localized specific changes in bone mineralization, remodeling and
defects within BML features that are adjacent to the subchondral plate. BMLs appear to be
sclerotic compared to unaffected regions; however, the mineral density in these lesions is
reduced and may render this area to be mechanically compromised, and thus susceptible to
attrition. Limited histological analysis of BMLs reveal thrombi, diffuse fibrinoid necrosis
and hyperplasia of blood vessel walls - all indicative of infarction-like pathology.
The aim of this research proposal is to create more specific targets and improve our
understanding of the pathology in BMLs.
Specific Aim 1:
- To collect tissue to evaluate protein and gene expression of these tissues and cultured
cells.
Although the presence of bone marrow lesions (BML) on MRI is strongly associated with
osteoarthritis (OA) progression and pain in some studies, the mechanism for this relation
and the underlying pathology is not well established. The lack of knowledge on what these
lesions constitute hampers their clinical utility both with regards to measurement and
targeting for therapeutic intervention.
Our preliminary data has localized specific changes in bone mineralization, remodeling and
defects within BML features that are adjacent to the subchondral plate. BMLs appear to be
sclerotic compared to unaffected regions; however, the mineral density in these lesions is
reduced and may render this area to be mechanically compromised, and thus susceptible to
attrition. Limited histological analysis of BMLs reveal thrombi, diffuse fibrinoid necrosis
and hyperplasia of blood vessel walls - all indicative of infarction-like pathology.
The aim of this research proposal is to create more specific targets and improve our
understanding of the pathology in BMLs.
Specific Aim 1:
- To collect tissue to evaluate protein and gene expression of these tissues and cultured
cells.
Inclusion Criteria:
- subjects having primary knee replacement surgery with 1 participating surgeon at NEBH
(principal investigator)
Exclusion Criteria:
- subjects having a revision knee replacement instead of a primary knee replacement
- contraindications for MRI
- pregnancy
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