Neurohumoral Control of Intestinal Electrical and Mechanical Activity



Status:Archived
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:February 2003
End Date:January 2011

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Trial Summary
Trial Overview
Inclusion Criteria

A collaborative research project with Dr. Kathleen Keef (Department of Physiology,
University of Nevada School of Medicine, Reno, Nevada) studying the role of putative
neurotransmitters in human intestine.


Segments of intestine from patients undergoing elective gastric bypass for morbid obesity or
resections for non-obstructive neoplasms at the UC Davis Medical Center will be used.
Samples will be taken from tissue normally removed and sent to Pathology or discarded. Full
thickness segments of intestine (10 mm x 1 mm) will be prepared for recording either
intracellular electrical activity or mechanical contraction. The effects of putative
non-adrenergic, non-cholinergic neurotransmitters (e.g., nitric oxide) will be studied. The
source of the tissue will not be identified either directly or indirectly through
identifiers associated with the measured responses.


We found this trial at
2
sites
University of California Irvine, 101 The City Drive S, Bldg. 22 C, Route 13
Orange, California 92868
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Orange, CA
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University of Nevada School of Medicine
Las Vegas, Nevada
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Las Vegas, NV
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