A Study of the Effectiveness of a Local Injection of Chemotherapy for Retinoblastoma
| Status: | Completed |
|---|---|
| Conditions: | Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/2/2016 |
| Start Date: | January 2009 |
| End Date: | April 2014 |
| Contact: | Carol L Shields, MD |
| Email: | carol.shields@shieldsoncology.com |
| Phone: | 215-928-3105 |
Intra-arterial (Ophthalmic Artery) Chemotherapy for Retinoblastoma
Over the past 15 years, intravenous chemotherapy has become the most popular conservative
(eye-saving) method for retinoblastoma treatment because it is often effective and usually
safe. In recent years, there has been much interest in providing highly focused (focal)
chemotherapy to a diseased organ including the liver, brain, and eye. With focused
chemotherapy, the chemotherapy drugs are injected directly into the ophthalmic artery (the
artery that supplies blood to the eye). A benefit of focal chemotherapy delivery is that it
decreases the chance of toxicity to other organs such as bone marrow suppression (causing
low blood counts) and the development of other cancers in the future.
(eye-saving) method for retinoblastoma treatment because it is often effective and usually
safe. In recent years, there has been much interest in providing highly focused (focal)
chemotherapy to a diseased organ including the liver, brain, and eye. With focused
chemotherapy, the chemotherapy drugs are injected directly into the ophthalmic artery (the
artery that supplies blood to the eye). A benefit of focal chemotherapy delivery is that it
decreases the chance of toxicity to other organs such as bone marrow suppression (causing
low blood counts) and the development of other cancers in the future.
The management of retinoblastoma includes systemic chemotherapy (carboplatin, etoposide, and
vincristine), thermotherapy, cryotherapy (freezing treatment), laser photocoagulation,
plaque radiotherapy, external beam radiotherapy, and enucleation. The treatment is tailored
to each individual case. Over the past 15 years, intravenous chemotherapy has risen as the
most popular conservative (eye-saving) method for retinoblastoma management because it is
effective and safe. In recent years, there has been keen interest in providing chemotherapy
more focally to a diseased organ including the liver, brain, and eye. The benefit of focal
chemotherapy delivery is to avoid toxicity to other organs and this toxicity includes the
risk of future cancers.
vincristine), thermotherapy, cryotherapy (freezing treatment), laser photocoagulation,
plaque radiotherapy, external beam radiotherapy, and enucleation. The treatment is tailored
to each individual case. Over the past 15 years, intravenous chemotherapy has risen as the
most popular conservative (eye-saving) method for retinoblastoma management because it is
effective and safe. In recent years, there has been keen interest in providing chemotherapy
more focally to a diseased organ including the liver, brain, and eye. The benefit of focal
chemotherapy delivery is to avoid toxicity to other organs and this toxicity includes the
risk of future cancers.
Inclusion Criteria:
- Advanced retinoblastoma in one or both eyes
- Recurrent retinoblastoma after failure of previous treatment
- No age limit (usually kids presenting with retinoblastoma present in the 1st two
decades of life)
- Judged by principal investigator to be medically and physically able to undergo the
procedure
Exclusion Criteria:
- Recurrent retinoblastoma which is treatable with other conservative measures
- Invasive retinoblastoma (retinoblastoma that has grown locally outside of the eye,
for example, into the bone around the eye)
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