First Line Hepato Cellular Carcinoma (HCC)
| Status: | Completed |
|---|---|
| Conditions: | Liver Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | May 2009 |
| End Date: | September 2013 |
A Randomized, Double-blind, Multi-center Phase III Study of Brivanib Versus Sorafenib as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma
The purpose of this study is to compare the overall survival of brivanib versus sorafenib in
subjects with advanced HCC who have not received prior systemic therapy.
subjects with advanced HCC who have not received prior systemic therapy.
For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com.
Inclusion Criteria:
- Histologic or cytologic confirmed diagnosis of HCC.
- Advanced HCC: disease not eligible for surgical and/or locoregional therapies OR
progressive disease after surgical and/or locoregional therapies
- Child-Pugh Class A
- ECOG performance status 0-1
- Adequate hematologic, hepatic, and renal function
Exclusion Criteria:
- Prior use of any systemic anti-cancer chemotherapy, immunotherapy or molecular
targeted agents for HCC
- History of active cardiac disease
- Thrombotic or embolic events within the past 6 months (except HCC tumor thrombus)
- Any other hemorrhage/bleeding event >= CTCAE Grade 3 within 8 weeks except for
esophageal or gastric varices
- Inability to swallow tablets or untreated malabsorption syndrome
We found this trial at
13
sites
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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James Graham Brown Cancer Center No one should feel compelled to leave Kentucky to seek...
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University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Mayo Clinic Arizona Mayo Clinic in Arizona provides medical care for thousands of people from...
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