Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Endocrine, Nephrology |
| Therapuetic Areas: | Endocrinology, Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/30/2018 |
| Start Date: | November 1998 |
| End Date: | December 2019 |
| Contact: | Kim Smoot |
| Email: | ksmoot@iuhealth.org |
| Phone: | 317-962-0869 |
Randall's Plaques: Pathogenesis and Relationship to Nephrolithiasis
Kidney stones are very common. They affect 3-5% of the population in the United States. Many
people are hospitalized for the treatment of kidney stones and some may die. Better
understanding of what causes kidney stones is useful in both the treatment and prevention of
kidney stones. However, exactly what causes kidney stones is unknown.
The most common type of kidney stones contains calcium, which sometimes is attached to a part
of the kidney important in producing the final urine, called the papilla. The investigators
have noticed that persons who form kidney stones seem to have more papilla with stones
attached. They propose to study these areas of the papilla, called Randall's plaques (named
after their discoverer), in patients undergoing surgery for kidney stones.
people are hospitalized for the treatment of kidney stones and some may die. Better
understanding of what causes kidney stones is useful in both the treatment and prevention of
kidney stones. However, exactly what causes kidney stones is unknown.
The most common type of kidney stones contains calcium, which sometimes is attached to a part
of the kidney important in producing the final urine, called the papilla. The investigators
have noticed that persons who form kidney stones seem to have more papilla with stones
attached. They propose to study these areas of the papilla, called Randall's plaques (named
after their discoverer), in patients undergoing surgery for kidney stones.
In order to attempt to explain the pathogenesis of renal calculi, the investigators videotape
and document the location and characteristics of each stone, papillae and calyces. One or
more small papillary biopsies are taken for analysis to help determine the point of origin of
the kidney stone and histological studies are undertaken to determine tissue differences
amongst different types of stone formers. Approximately one month after surgery, metabolic
studies are undertaken to further review potential causes of stone formation.
and document the location and characteristics of each stone, papillae and calyces. One or
more small papillary biopsies are taken for analysis to help determine the point of origin of
the kidney stone and histological studies are undertaken to determine tissue differences
amongst different types of stone formers. Approximately one month after surgery, metabolic
studies are undertaken to further review potential causes of stone formation.
Inclusion Criteria:
- Patients of Methodist Urology in Indianapolis, IN who are undergoing endoscopic
procedures for nephrolithiasis or other urologic disease.
- Upper urinary tract endoscopic or PERC procedure for kidney stones removal
- General medical health allowing surgical procedure
- Ability to complete all the necessary components of the study
- Able to sign an informed consent
Exclusion Criteria:
- Poor general medical health
- Bleeding diathesis
- Inability or unwillingness to comply with post-surgical follow-up
We found this trial at
1
site
Indianapolis, Indiana 46202
Principal Investigator: James Lingeman, MD
Phone: 317-962-0869
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