Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/30/2019
Start Date:July 9, 2009
End Date:November 2020

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A Randomized, Double-Blind, Placebo-Controlled Trial Of Neratinib (HKI-272) After Trastuzumab In Women With Early-Stage HER-2/Neu Overexpressed/Amplified Breast Cancer

The purpose of this study is to investigate whether neratinib can further reduce the risk of
recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment
with trastuzumab.


Inclusion Criteria:

- Stage II through IIIC HER-2/erbB-2 positive breast cancer with node positive disease.

- Been treated for early breast cancer with standard of care duration of trastuzumab.

- Could have been treated neoadjuvantly but have not reached pathologic complete
response.

Exclusion Criteria:

- Positive clinical and radiologic assessments for local or regional recurrence of
disease at the time of study entry.

- History of heart disease.

- Corrected QT (QTc) interval >0.45 seconds

- History of gastrointestinal disease with diarrhea as the major symptom.
We found this trial at
186
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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3525
Lakeland, Florida 33805
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2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
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1871 SE Tiffany Ave # 100
Port Saint Lucie, Florida 34952
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
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427 West 3rd Avenue
Albany, Georgia 31701
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901 Leighton Avenue
Anniston, Alabama 36207
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Ashland, Kentucky 41101
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Atlanta, Georgia 30318
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820 Saint Sebastian Way
Augusta, Georgia 30901
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Austin, Texas 78731
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227 Saint Paul Place
Baltimore, Maryland 21202
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9103 Franklin Square Drive
Baltimore, Maryland 21237
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Baton Rouge, Louisiana 70809
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Bedford, Texas 76022
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Bethlehem, Pennsylvania 18015
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Beverly Hills, California 90021
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900 E Broadway Ave
Bismarck, North Dakota 58501
(701) 530-5550
Mid Dakota Clinic, PC We're your family clinic, with the doctors you know and trust...
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Boynton Beach, Florida 33426
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Bronx, New York 10469
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Charleston, South Carolina 29403
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979 East 3rd Street
Chattanooga, Tennessee 37403
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Cherry Hill, New Jersey 08003
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Cincinnati, Ohio 45219
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2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
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2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
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115 North Sumter Street
Columbia, South Carolina 29203
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100 Medical Park Drive Northeast
Concord, North Carolina 28025
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Cookeville, Tennessee 38501
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Corpus Christi, Texas 78463
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Corpus Christi, Texas 78374
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Denton, Texas 76210
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20 Duke Medicine Circle
Durham, North Carolina 27710
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Elizabeth, New Jersey 07207
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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401 East Cheves Street
Florence, South Carolina 29506
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Gilroy, California 95020
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1509 Wilson Terrace
Glendale, California 91206
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233 Fulton Street East
Grand Rapids, Michigan 49503
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2845 Greenbrier Rd
Green Bay, Wisconsin 54311
(920) 288-8000
Aurora BayCare Medical Center Aurora BayCare Medical Center is a 167-bed, full-service hospital serving the...
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Greenbrae, California 94904
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4300 Londonderry Road
Harrisburg, Pennsylvania 17109
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Hilton Head Island, South Carolina 29926
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888 S King St
Honolulu, Hawaii 96813
(808) 522-4000
Straub Clinic And Hospital Founded in 1921, Straub Clinic & Hospital is a fully integrated...
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Houston, Texas 77024
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6550 Fannin Street
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Houston, Texas 77055
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1915 White Ave.
Knoxville, Tennessee 37916
(865) 541-1678
Thompson Cancer Survival Center The Thompson Cancer Survival Center Downtown facility has pioneered many advances...
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Lake Success, New York 11042
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300 Main Street
Lewiston, Maine 04240
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94 Old Short Hills Road
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12993 Southern Boulevard
Loxahatchee Groves, Florida 33470
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Marrero, Louisiana 70072
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