Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/30/2019
Start Date:July 9, 2009
End Date:November 2020

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-Blind, Placebo-Controlled Trial Of Neratinib (HKI-272) After Trastuzumab In Women With Early-Stage HER-2/Neu Overexpressed/Amplified Breast Cancer

The purpose of this study is to investigate whether neratinib can further reduce the risk of
recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment
with trastuzumab.


Inclusion Criteria:

- Stage II through IIIC HER-2/erbB-2 positive breast cancer with node positive disease.

- Been treated for early breast cancer with standard of care duration of trastuzumab.

- Could have been treated neoadjuvantly but have not reached pathologic complete
response.

Exclusion Criteria:

- Positive clinical and radiologic assessments for local or regional recurrence of
disease at the time of study entry.

- History of heart disease.

- Corrected QT (QTc) interval >0.45 seconds

- History of gastrointestinal disease with diarrhea as the major symptom.
We found this trial at
186
sites
Christ Hospital Cancer Center
Cincinnati, Ohio 45219
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Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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Barbara Ann Karmanos Cancer Institute
4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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Detroit, MI
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Lakeland Regional Cancer Center
3525
Lakeland, Florida 33805
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Lakeland, FL
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Vanderbilt-Ingram Cancer Center
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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Nashville, TN
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M.D. Anderson Cancer Center at Orlando
1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
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Orlando, FL
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Hematology Oncology Associates of Treasure Coast
1871 SE Tiffany Ave # 100
Port Saint Lucie, Florida 34952
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Port Saint Lucie, FL
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Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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Wenatchee Valley Medical Center
820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
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Phoebe Cancer Center
427 West 3rd Avenue
Albany, Georgia 31701
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Albany, GA
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Anniston Oncology
901 Leighton Avenue
Anniston, Alabama 36207
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Anniston, AL
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Ashland Bellefonte Cancer Center
Ashland, Kentucky 41101
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Ashland, KY
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Piedmont Cancer Institute, P.C.
Atlanta, Georgia 30318
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Atlanta, GA
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Augusta Oncology Associates (ACORN), P.C.
820 Saint Sebastian Way
Augusta, Georgia 30901
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Augusta, GA
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Texas Oncology
Austin, Texas 78731
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Innovative Medical Research of South Florida Inc.
Aventura, Florida 33180
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Aventura, FL
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Medical Oncology & Hematology Mercy Medical Center
227 Saint Paul Place
Baltimore, Maryland 21202
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Baltimore, MD
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Harry and Jeanette Weinberg Cancer Center
9103 Franklin Square Drive
Baltimore, Maryland 21237
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Baltimore, MD
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Hematology-Oncology Clinic
Baton Rouge, Louisiana 70809
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Texas Oncology, P.A.
Bedford, Texas 76022
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Bend Memorial Clinic
Bend, Oregon 97701
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Bend, OR
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Southwestern Vermont Regional Cancer Center
Bennington, Vermont 05201
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Bennington, VT
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Oncology Hematology of Lehigh Valley
Bethlehem, Pennsylvania 18015
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Bethlehem, PA
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Cedars-Sinai Medical Group
Beverly Hills, California 90021
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Beverly Hills, CA
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Birmingham Hematology and Oncology Associates, LLC
Birmingham, Alabama 35205
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Birmingham, AL
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Mid Dakota Clinic, PC
900 E Broadway Ave
Bismarck, North Dakota 58501
(701) 530-5550
Mid Dakota Clinic, PC We're your family clinic, with the doctors you know and trust...
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University Cancer Institute, LLC
Boynton Beach, Florida 33426
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Eastchester Center for Cancer Care
Bronx, New York 10469
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Bronx, NY
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Charleston Hematology/Oncology Associates, Pa
Charleston, South Carolina 29403
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Medical University of South Carolina Hollings Cancer Center
Charleston, South Carolina 29425
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Charleston, SC
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University Hematology/Oncology Associates PLLC
979 East 3rd Street
Chattanooga, Tennessee 37403
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Chattanooga, TN
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The Center for Cancer and Hematologic Disease
Cherry Hill, New Jersey 08003
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Cherry Hill, NJ
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Rush University Medical Center
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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University of Cincinnati
2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
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University Hospitals of Cleveland Medical Center
Cleveland, Ohio 44012
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Cleveland, OH
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MetroHealth Med Ctr
2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
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Francisco Gonzalez MD PA
115 North Sumter Street
Columbia, South Carolina 29203
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Columbia, SC
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NorthEast Oncology Associates Carolinas Medical Center NorthEast
100 Medical Park Drive Northeast
Concord, North Carolina 28025
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Concord, NC
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Cookeville Regional Cancer Center
Cookeville, Tennessee 38501
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Cookeville, TN
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Coastal Bend Cancer Center
Corpus Christi, Texas 78463
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Corpus Christi, TX
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South Texas Institute of Cancer
Corpus Christi, Texas 78374
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Corpus Christi, TX
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Cancer Specialists Of South Texas, Pa
Corpus Christi, Texas 78412
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Corpus Christi, TX
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Samaritan Hematology & Oncology Consultants
Corvallis, Oregon 97330
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Corvallis, OR
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Center for Oncology Research
Dallas, Texas 75230
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Dallas, TX
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Texas Oncology, PA
Dallas, Texas 75246
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Texas Oncology-Baylor Charles A. Sammons Cancer Center
Dallas, Texas 75246
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University of Texas Southwestern Medical Center Simmons Cancer Center
2201 Inwood Road
Dallas, Texas 75390
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Dallas, TX
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Cancer Care Specialists of Illinois, Decatur Memorial Hospital Clinical Research
210 West McKinley Avenue
Decatur, Illinois 62526
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Decatur, IL
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North Broward Medical Center
Deerfield Beach, Florida 33064
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Deerfield Beach, FL
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Texas Oncology, P.A.
Denton, Texas 76210
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Denton, TX
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Duke University Medical Center Medical Oncology
20 Duke Medicine Circle
Durham, North Carolina 27710
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Durham, NC
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El Paso Cancer Treatment Ctr - West
El Paso, Texas 79902
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El Paso, TX
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The Center for Integrative Cancer Medicine
El Paso, Texas 79902
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El Paso, TX
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Trinitas Comprehensive Cancer Center
Elizabeth, New Jersey 07207
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Elizabeth, NJ
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Medical Oncology and Hematology Associates of Northern Virginia
Fairfax, Virginia 22031
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Fairfax, VA
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Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Fairfax, VA
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McLeod Oncology and Hematology Associates
401 East Cheves Street
Florence, South Carolina 29506
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Florence, SC
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Dwight David Eisenhower Army Medical Center
Fort Gordon, Georgia 30905
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Fort Gordon, GA
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Broward General Medical Center
Fort Lauderdale, Florida 33316
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Fort Lauderdale, FL
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Texas Oncology P.A.
Fort Worth, Texas 76104
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Fort Worth, TX
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Florida Cancer Specialists & Research Institute
Gainesville, Florida 32605
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Gainesville, FL
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Texas Oncology PA
Garland, Texas 75042
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Garland, TX
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The Jones Clinic, PC
Germantown, Tennessee 38138
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Germantown, TN
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Gettysburg Cancer Center
Gettysburg, Pennsylvania 17325
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Gettysburg, PA
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Ronald Yanagihara MD - PP
Gilroy, California 95020
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Gilroy, CA
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Glendale Adventist Medical Center Cancer Services
1509 Wilson Terrace
Glendale, California 91206
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Glendale, CA
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Cancer and Hematology Centers of Western Michigan
Grand Rapids, Michigan 49503
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Grand Rapids, MI
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Medical Specialty Associates
233 Fulton Street East
Grand Rapids, Michigan 49503
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Grand Rapids, MI
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Aurora BayCare Medical Center
2845 Greenbrier Rd
Green Bay, Wisconsin 54311
(920) 288-8000
Aurora BayCare Medical Center Aurora BayCare Medical Center is a 167-bed, full-service hospital serving the...
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California Cancer Care
Greenbrae, California 94904
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Greenbrae, CA
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Pinnacle Health Cancer Center Community Campus
4300 Londonderry Road
Harrisburg, Pennsylvania 17109
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Harrisburg, PA
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Beaver Medical Group, L.P.
Highland, California 92346
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Highland, CA
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South Carolina Cancer Specialists
Hilton Head Island, South Carolina 29926
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Hilton Head Island, SC
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Straub Clinic And Hospital
888 S King St
Honolulu, Hawaii 96813
(808) 522-4000
Straub Clinic And Hospital Founded in 1921, Straub Clinic & Hospital is a fully integrated...
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Honolulu, HI
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Texas Oncology - Memorial City
Houston, Texas 77024
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Houston, TX
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The Methodist Hospital Breast Center
6550 Fannin Street
Houston, Texas 77030
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Houston, TX
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Medicus Alliance Clinical Research Org., Inc.
14090 Southwest Freeway
Houston, Texas 77055
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Houston, TX
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Jabboury Foundation for Cancer Research, Inc.
Houston, Texas 77082
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Houston, TX
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Central Indiana Cancer Centers
Indianapolis, Indiana 46227
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Indianapolis, IN
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Hematology Oncology of Indiana
Indianapolis, Indiana 46260
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Indianapolis, IN
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Capitol Comprehensive Cancer Care Clinic
Jefferson City, Missouri 65109
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Jefferson City, MO
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Midwest Center for Hematology/Oncology
Joliet, Illinois 60432
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Joliet, IL
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Northeast Arkansas Clinic
Jonesboro, Arkansas 72401
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Jonesboro, AR
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Cascade Cancer Center
Kirkland, Washington 98034
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Kirkland, WA
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Thompson Cancer Survival Center
1915 White Ave.
Knoxville, Tennessee 37916
(865) 541-1678
Thompson Cancer Survival Center The Thompson Cancer Survival Center Downtown facility has pioneered many advances...
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Knoxville, TN
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ProHEALTH Care Associates
Lake Success, New York 11042
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Lake Success, NY
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Central Maine Healthcare Corp
300 Main Street
Lewiston, Maine 04240
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Lewiston, ME
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Southeast Nebraska Hematology & Oncology Consultants
Lincoln, Nebraska 68510
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Lincoln, NE
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Saint Barnabas Health Care System
94 Old Short Hills Road
Livingston, New Jersey 07039
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Livingston, NJ
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Breastlink Med Group Inc
Long Beach, California 90806
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Long Beach, CA
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Long Beach Memorial Medical Center
Long Beach, California 90801
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Long Beach, CA
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Hematology Oncology Associates
12993 Southern Boulevard
Loxahatchee Groves, Florida 33470
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Loxahatchee Groves, FL
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Crescent City Research Consortium, LLC
Marrero, Louisiana 70072
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Marrero, LA
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Signal Point Hematology/Oncology
Middletown, Ohio 45042
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Minnesota Oncology and Hematology, PA
Minneapolis, Minnesota 55405
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Facey Medical Group
Mission Hills, California
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Montana Cancer Specialists
Missoula, Montana 59802
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Medical Arts Associates, Ltd
Moline, Illinois 61265
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Sweeney-Melenyser Pavillion
Monongahela, Pennsylvania 15063
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West Virginia University/Mary Babb Randolph Cancer Center
Morgantown, West Virginia 26506
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Summit Medical Group
Morristown, New Jersey 07960
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