Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index

Several environmental factors and comorbid conditions have been found to be associated with
psoriasis in adults, including obesity, depression, smoking, and other cardiovascular risk
factors such as high blood pressure. The object of this research study is to examine these
associations in children as very little is known about psoriasis and cardiovascular risk
factors in the pediatric population.

This is a multi-center study with a planned total enrollment of about 200 subjects ages 2-17
years old with psoriasis and 100 aged-match controls. Patient and family history will be
recorded. All subjects will undergo standard height, weight, blood pressure, and waist
circumference (WC). For the obese and overweight subjects we will also obtain their growth
charts to attempt to correlate weight gain with psoriasis onset and progression. All data
will be compiled and then statistically analyzed.

Inclusion Criteria:

- Subjects must be between the ages of 5 and 17 years at the time of enrollment.

- Subjects of either sex.

- Subjects who have had psoriatic plaques for more than 6 months.

- Subjects and guardians of minors must sign the approved IRB consent form(s) prior to
initiation of the study protocol.

- Subjects enrolled as "non-inflammatory" normal controls will carry a common non-
systemic skin condition, such as acne, nevi, warts and molluscum as their main
diagnosis.

- Subjects enrolled as "inflammatory" normal controls will carry a diagnosis of
moderate to severe atopic dermatitis.

Exclusion Criteria:

- Subjects who are unable to give informed consent or assent.

- Subjects who have had psoriasis for less than 6 months.

- Subjects whose condition is deemed unsafe or incapable by the study investigator for
study participation.