Cardiovascular and Metabolic Responses to a Mixed Meal
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 50 |
| Updated: | 4/21/2016 |
| Start Date: | January 2009 |
| End Date: | August 2011 |
Role of Exercise Training and Body Weight on Cardiovascular and Metabolic Responses to a Mixed Meal Tolerance Test
The purpose is to determine whether regular endurance exercise and/or body weight influence
the way our nervous and vascular systems respond during the metabolism of meals.
the way our nervous and vascular systems respond during the metabolism of meals.
To begin to examine this question we recruited healthy endurance-trained (high fit, HF) and
normally active (average fit, AF) subjects. It is well characterized that chronic endurance
training results in enhanced peripheral insulin sensitivity. Therefore, our rationale was
that inclusion of two healthy subject groups, with distinct differences in insulin
sensitivity, would allow us to investigate how enhanced insulin sensitivity influences
insulin-mediated changes in central sympathetic outflow. Direct measurements of central
sympathetic outflow to skeletal muscle (i.e., MSNA) were recorded, and a mixed meal was used
as a physiological method to evoke robust and sustained increases in MSNA, which have been
primarily attributed to insulin. We hypothesized that HF subjects would have a greater MSNA
response, for a given plasma insulin concentration, following consumption of a mixed meal
(i.e., greater central insulin sensitivity).
normally active (average fit, AF) subjects. It is well characterized that chronic endurance
training results in enhanced peripheral insulin sensitivity. Therefore, our rationale was
that inclusion of two healthy subject groups, with distinct differences in insulin
sensitivity, would allow us to investigate how enhanced insulin sensitivity influences
insulin-mediated changes in central sympathetic outflow. Direct measurements of central
sympathetic outflow to skeletal muscle (i.e., MSNA) were recorded, and a mixed meal was used
as a physiological method to evoke robust and sustained increases in MSNA, which have been
primarily attributed to insulin. We hypothesized that HF subjects would have a greater MSNA
response, for a given plasma insulin concentration, following consumption of a mixed meal
(i.e., greater central insulin sensitivity).
Inclusion Criteria:
- healthy, not currently taking any medications
Exclusion Criteria:
- unhealthy, taking medications
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