Ghrelin and Insulin Resistance
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | August 2011 |
| End Date: | December 2016 |
Role of Ghrelin in the Improvement of Insulin Resistance After Roux-en-Y Gastric Bypass Surgery
Ghrelin, a hormone produced in the stomach that stimulates hunger and food intake, declines
immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an
individual's ability to respond to insulin. The purpose of this study is to determine if the
decline in ghrelin levels after weight loss surgery contributes to the improvement of
insulin sensitivity.
immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an
individual's ability to respond to insulin. The purpose of this study is to determine if the
decline in ghrelin levels after weight loss surgery contributes to the improvement of
insulin sensitivity.
Inclusion Criteria:
- Age 18-65
- BMI > 35 kg/m2
- Scheduled for bariatric surgery at Vanderbilt University Medical Center
Inclusion for Control group:
- Age 18-65
- BMI < 30kg/m2
Exclusion Criteria:
- Prior bariatric surgery
- Serum creatinine > 1/5 mg/dl
- Hepatic enzyme elevations > 2x upper limits of normal
- Current use of warfarin or clopidogrel
- Intercurrent infections
- Females with positive pregnancy test
- Abnormal ECG
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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