Chronic Obstructive Pulmonary Disease (COPD) and Domestic Endotoxin (CODE)
| Status: | Completed |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 40 - 100 |
| Updated: | 10/5/2017 |
| Start Date: | July 2008 |
| End Date: | November 2014 |
COpd and Domestic Endotoxin (CODE)
This project aims to characterize the independent effect of domestic endotoxin exposure on
health status, as well as pulmonary and systemic inflammation, in former smokers with COPD.
Positive findings from this study would be clinically relevant, as they would provide
evidence to support aggressive reduction of ongoing endotoxin exposure in patients with COPD.
The investigators also hope to make a methodological advance in the field of endotoxin
exposure assessment by elucidating whether settled dust and/or airborne endotoxin
measurements are the more relevant exposure of interest in epidemiological studies of
respiratory disease. To fulfill the specific aims, the investigators will conduct a
longitudinal study, including 75 former smokers with COPD. All subjects will have indoor air
monitoring, in-home settled dust collections, home inspections as well as assessments of
health status, quality of life (QOL), lung function and pulmonary and systemic inflammation.
health status, as well as pulmonary and systemic inflammation, in former smokers with COPD.
Positive findings from this study would be clinically relevant, as they would provide
evidence to support aggressive reduction of ongoing endotoxin exposure in patients with COPD.
The investigators also hope to make a methodological advance in the field of endotoxin
exposure assessment by elucidating whether settled dust and/or airborne endotoxin
measurements are the more relevant exposure of interest in epidemiological studies of
respiratory disease. To fulfill the specific aims, the investigators will conduct a
longitudinal study, including 75 former smokers with COPD. All subjects will have indoor air
monitoring, in-home settled dust collections, home inspections as well as assessments of
health status, quality of life (QOL), lung function and pulmonary and systemic inflammation.
Inclusion Criteria:
- Patient reported physician diagnosis of COPD/Chronic Bronchitis/Emphysema
- Cigarette Smoking > 10 pack-years
- Age > 40 years
- Has not smoked > 1 year
- Post BD FEV1/FVC ≤ 70%
- Post BD FEV1 (% predicted) 30-80%
- Ability and willingness to provide consent
Exclusion Criteria:
- Non- English speaking
- Planning to move or live away from the home during the study period
- Co-morbid illnesses such as:
- Current physician diagnosis of Asthma
- Other pulmonary diseases
- Systemic disease requiring treatment with immunosuppressive agents
- Known alpha-1 antitrypsin deficiency
- Occupational exposure with high endotoxin exposure
- Within the last 6 months Use of oral corticosteroids
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