National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Cardiology, Neurology, Orthopedic |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology, Orthopedics / Podiatry, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 12/21/2016 |
| Start Date: | November 2007 |
| End Date: | September 2016 |
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular
Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute
(NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be
related to thoracic aortic aneurysms and collected medical data and biologic samples. The
study ended in September 2016. Data and samples are available from NHLBI and requests should
be made to BioLINCC. See the NHLBI website for more information:
https://www.nhlbi.nih.gov/research/resources/gentac/.
Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute
(NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be
related to thoracic aortic aneurysms and collected medical data and biologic samples. The
study ended in September 2016. Data and samples are available from NHLBI and requests should
be made to BioLINCC. See the NHLBI website for more information:
https://www.nhlbi.nih.gov/research/resources/gentac/.
Eligible subjects must have one of the conditions listed below and be enrolled in-person
at one of the participating clinical centers.Contact the study coordinator at the location
nearest you for more information about participation.
- Marfan syndrome
- Turner syndrome
- Ehlers-Danlos syndrome
- Loeys-Dietz syndrome
- FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 genetic mutation
- Bicuspid aortic valve without known family history
- Bicuspid aortic valve with family history
- Bicuspid aortic valve with coarctation
- Familial Thoracic Aortic Aneurysm and DissectionsYes
- Shprintzen-Goldberg syndrome
- Other aneurysms and dissections of the thoracic aorta not due to trauma, <50yo
- Other congenital heart disease (e.g., Tetralogy of Fallot, coarctation)
Exclusion Criteria:
- Inability of the patient, parent or guardian to give consent.
- Unwillingness to provide a blood or buccal specimen.
We found this trial at
7
sites
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
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Queen's Medical Center The Queen's Medical Center, located in downtown Honolulu, Hawaii, is a private,...
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