fMRI Study of a Dual Process Treatment Protocol With Substance Dependent Adults

The substance abuse literature consistently shows that negative emotional states and
subjective stress are highly predictive of relapse and significantly influence behavioral
motivation. From a neurobiological perspective, stress associated with withdrawal and
substance abuse experiences stimulates chemical and hormonal changes in the brain creating a
protracted hyperaroused state. Further, cognitive control resources (i.e., cognitive coping
skills/relapse prevention training) have been shown to exert minimal impact on behavioral
decision-making in the presence of intense affective material. Thus, implicit cognitive
processes play a significant role in drug use behavior, decreasing self regulation capacities
and increasing risk of. Specifically, high levels of stress can compromise prefrontal cortex
functioning, with the nucleus accumbens, orbitofrontal cortex and amygdala functional changes
related to increased cue reactivity.

Taken together, the current literature strongly suggests that verbally-based therapies may
have limited utility as a singular form of treatment in early substance abuse recovery, as
the brain may not be functionally ready for executive level processing. Instead, the
multidisciplinary substance abuse literature suggests that psychosocial treatment methods
need to include a range of learning approaches that allow for visual-sensory processing, in
addition to traditional verbal-based processing. Integrated multi-modal interventions are
needed to offer opportunities for activation of these different brain regions to facilitate
cognitive-affective balance in behavioral decision-making.

Study Inclusion Criteria:

- Age < 18 years old

- Signed informed consent for this study

- History of chemical dependency

- Meets Inova CATS Relapse Prevention admission criteria

- Must have at least 60 days of sobriety prior to admission with documentation of
negative drug and alcohol screening

- Documentation of HIV negative test result (completed in the past year)

- Willing and able to attend an out-patient drug treatment group for two hours twice a
week for 10 weeks

- Willing to complete study-required evaluations (including assessments, questionnaires,
drug/alcohol testing, week 8 qualitative interview)

- A score < 25 on the MoCA (Montreal Cognitive Assessment)

Study Exclusion Criteria:

- History of taking "anti-craving" medication in the past 90 days

- Other medical illness or florid psychiatric symptoms that would render the participant
inappropriate for study participation

- History of receiving treatment for addictions other than substance use (i.e. food,
gambling, sex)

- Clinical determination of dementia or organic brain syndrome

- History of major head injury

- Incapable of consenting for themselves due to cognitive impairment

- Enrollment in another study that might interfere with analysis of this study

Additional Inclusion Criteria for fMRI sub-study:

- Willing and able to participate in the fMRI arm of the study

- If of childbearing capacity, must have negative screening urine pregnancy test and be
willing to use birth control as specified in the consent document

Additional Exclusion Criteria for fMRI sub-study:

- Left-handed

- Cardiac pacemakers or other body metals

- Other criteria identified on the "MRI Screening Form" that would indicate that having
an MRI would be unsafe

- Pregnancy

- Claustrophobia (for the fMRI testing)

- Muscular or back problems that would prevent participant from being able to lie in the
scanner for 90 minutes