The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | April 2011 |
| Contact: | Farid Sadaka, MD |
| Email: | farid.sadaka@mercy.net |
| Phone: | 314-251-6486 |
The Effect of Three Different Fluids(Albumin 5%, Normal Saline, HES 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients Using Sidestream Dark Field (SDF) Microscopy and Near-Infrared Spectroscopy (NIRS) Analysis
Major microvascular blood flow alterations have been documented in patients with severe
sepsis. It was also demonstrated that the microcirculation improved in survivors of septic
shock but failed to do so in patients dying from acute circulatory failure or with multiple
organ failure after shock resolution. Early, effective fluid resuscitation is a key
component in the management of patients with severe sepsis and septic shock with the goal of
improving tissue perfusion. The best fluid in this early resuscitation phase has been and
still is under debate. The aim of this study is to evaluate the effect of Three different
Fluids(Albumin 5%, Normal Saline, HES 130 kD) on microcirculation in severe sepsis/septic
shock patients using Sidestream Dark Field (SDF) Microscopy and Near-Infrared Spectroscopy
(NIRS) analysis.
sepsis. It was also demonstrated that the microcirculation improved in survivors of septic
shock but failed to do so in patients dying from acute circulatory failure or with multiple
organ failure after shock resolution. Early, effective fluid resuscitation is a key
component in the management of patients with severe sepsis and septic shock with the goal of
improving tissue perfusion. The best fluid in this early resuscitation phase has been and
still is under debate. The aim of this study is to evaluate the effect of Three different
Fluids(Albumin 5%, Normal Saline, HES 130 kD) on microcirculation in severe sepsis/septic
shock patients using Sidestream Dark Field (SDF) Microscopy and Near-Infrared Spectroscopy
(NIRS) analysis.
Inclusion Criteria:
- Adult patients will be enrolled within 24 hrs of onset of severe sepsis/septic shock
with an indication for fluid bolus administration.
Exclusion Criteria:
- Liver cirrhosis
- shock from other causes
- Oral injuries (precluding SDF imaging)
- Severe peripheral vascular disease, dialysis fistula, or mastectomies precluding safe
forearm occlusion
- Age < 18 years
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