Relative Bioavailability Study for GSK1278863A

A randomized, open label, 3-period crossover study in healthy subjects. The primary
objective of this study is to determine the relative bioavailability of GSK1278863A after
single oral doses of 100mg GSK1278863A tablets with particle sizes of 13, 29, or 41
micrometers (um) in healthy subjects.

Inclusion Criteria:

- AST, ALT, alkaline phosphatase and bilirubin <= 1.5xULN (isolated bilirubin >1.5xULN
is acceptable if bilirubin is fractionated and direct bilirubin <35%).

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including: medical history, physical examination, laboratory tests and
cardiac monitoring. A subject with a clinical abnormality or laboratory parameters
outside the reference range for the population being studied may be included only if
the Investigator and the GSK Medical Monitor agree that the finding is unlikely to
introduce additional risk factors and will not interfere with the study procedures.

- Male or female between 18 and 55 years of age inclusive, at the time of signing the
informed consent.

- A female subject is eligible to participate if she is of: Non-childbearing potential
defined as pre-menopausal females with a documented tubal ligation or hysterectomy;
or postmenopausal defined as 12 months of spontaneous amenorrhea.

- Male subjects with female partners of child-bearing potential must agree to use
contraception methods

- Body weight >=50kg and BMI within the range 19 to 29.9kg/m2 (inclusive).

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

- QTcB or QTcF < 450 msec; or QTc < 480 msec in subjects with Bundle Branch Block.

- Subjects must have a normal resting blood pressure, after having rested quietly in a
supine position for at least 15 minutes, defined as: >=100mm Hg systolic/60mm Hg
diastolic and <=140mm Hg systolic/90mm Hg diastolic.

Exclusion Criteria:

- Any clinically relevant abnormality identified on the screening medical assessment,
laboratory examination, or ECG (12 lead) judged by the Investigator and /or medical
monitor to potentially introduce additional risk factors and/or interfere with the
study procedures.

- Significant cardiac, pulmonary, metabolic, renal, hepatic, neurological, psychiatric,
or gastrointestinal conditions that in the opinion of the investigator and/or GSK
medical monitor, places the subject at an unacceptable risk as participant in this
trial.

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening

- Current or chronic history of liver disease, or known hepatic or biliary
abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).

- A positive pre-study drug/alcohol screen.

- A positive test for HIV antibody.

- CPK above the normal range.

- Calculated creatinine clearance: <80mL/min.

- Subjects with a pre-exisisting condition interfering with normal gastrointestinal
anatomy or motility, and/or hepatic function-that could interfere with the
absorption, metabolism, and/or excretion of the study drugs.

- History of regular alcohol consumption within 6 months of the study defined as: an
average weekly intake of >21 drinks for males or >14 drinks for females. One drink is
equivalent to 12 g of alcohol: 12 ounces (360 ml) of beer, 5 ounces (150 ml) of wine
or 1.5 ounces (45 ml) of 80 proof distilled spirits.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- History of peptic ulcer disease or of chronic rectal bleeding.

- History of malignancy. Non-melanoma skin cancer that has been definitively removed is
allowed.

- Subjects with a baseline medical history of proliferative diabetic retinopathy,
preproliferative diabetic retinopathy, or wet age-related macular degeneration (AMD).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.

- Use of prescription or non-prescription drugs, including vitamins, herbal and dietary
supplements within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5
half-lives (whichever is longer) prior to the first dose of investigational product.

- History of sensitivity to any of the investigational products, or components thereof
or a history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 56 day period.

- Pregnant females as determined by positive serum or urine hCG test at screening or
prior to dosing.

- Lactating females.

- Unwillingness or inability to follow the procedures outlined in the protocol.

- Subject is mentally or legally incapacitated.

- History or sensitivity to heparin or heparin-induced thrombocytopenia.

- Urinary cotinine levels indicative of smoking. History or regular use of tobacco or
nicotine-containing products within 6 months prior to screening.

- Consumption of >3 servings per day of red wine, grapefruit (juice), blood orange
(juice), star fruit, onions, kale, broccoli, green beans, or apples from 7 days prior
to the first dose of investigational product, unless in the opinion of the
Investigator and GSK Medical Monitor this will not interfere with the study
procedures and compromise subject safety.