Measurement of Kidney Blood Flow and Oxygen Levels by MRI

The traditional measurement of renal blood flow in ml/min involves the collection of multiple
blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is
given. In this study, the investigators determine the ability of MRI to estimate renal blood
flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar
to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both
performed on the same day.

Inclusion Criteria:

In this study, the investigators will enroll 16 men and women aged ≥ 18 years with Stage II
- V chronic kidney disease (CKD). In addition, the investigators will enroll 4 subjects
with a glomerular filtration rate (GFR) of greater than 60 ml/min who do not have any
evidence of CKD.

Exclusion Criteria:

This study excludes those not suitable for MRI or for the interventional pharmacologic
procedures.