Probiotics in Infants With Gastroschisis
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/15/2018 |
| Start Date: | March 2011 |
| End Date: | August 2015 |
Infants born with gastroschisis usually require surgery shortly after birth. After surgery
the intestine is often unable to digest human milk or formula for weeks or months. During
this time the baby has to remain in the hospital to receive special nutrition through an IV.
How bacteria colonize the intestine in these babies is unknown. Probiotics are bacteria that
appear to have beneficial effects on digestion. This study will test whether giving probiotic
bacteria to babies after surgery for gastroschisis will change the bacteria in the intestine
to be more like those of a healthy breast-fed baby.
the intestine is often unable to digest human milk or formula for weeks or months. During
this time the baby has to remain in the hospital to receive special nutrition through an IV.
How bacteria colonize the intestine in these babies is unknown. Probiotics are bacteria that
appear to have beneficial effects on digestion. This study will test whether giving probiotic
bacteria to babies after surgery for gastroschisis will change the bacteria in the intestine
to be more like those of a healthy breast-fed baby.
Infants with gastroschisis have decreased intestinal motility. This decrease in intestinal
motility delays the introduction and advancement of feeds which prolongs hospitalization. The
use of probiotic bacteria may improve intestinal motility. It is unknown whether the
intestinal microbiota of infants with gastroschisis differs from that of healthy infants
without gastroschisis and whether probiotics will change the microbiota. The primary outcome
in this study is the composition of the fecal microbiota in infants with gastroschisis
following surgical correction treated with Bifidobacterium infantis or placebo. We will also
look at differences in hospital length of stay.
motility delays the introduction and advancement of feeds which prolongs hospitalization. The
use of probiotic bacteria may improve intestinal motility. It is unknown whether the
intestinal microbiota of infants with gastroschisis differs from that of healthy infants
without gastroschisis and whether probiotics will change the microbiota. The primary outcome
in this study is the composition of the fecal microbiota in infants with gastroschisis
following surgical correction treated with Bifidobacterium infantis or placebo. We will also
look at differences in hospital length of stay.
Inclusion Criteria:
- Gastroschisis
- Born at or transferred to UC Davis Children's hospital
Exclusion Criteria:
We found this trial at
1
site
Sacramento, California 95817
Principal Investigator: Mark Underwood, MD
Phone: 916-703-3050
Click here to add this to my saved trials
