Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
| Status: | Completed |
|---|---|
| Conditions: | Endocrine, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 1/19/2018 |
| Start Date: | January 2012 |
| End Date: | October 2016 |
The Effect of a Long-term Medium Chain Supplemented Diet on Cognitive Function and Brain Activation During Hypoglycemia in Type 1 Diabetes.
Insulin treatment often causes the blood glucose levels to fall too low (hypoglycemia).
Hypoglycemia can be associated with confusion and disorientation as well as other symptoms
such as palpitations, sweating and tremors. Medium chain triglycerides (MCT) can be used as a
fuel in the brain during low blood sugar levels and therefore may prevent or reduce some of
the confusion and disorientation seen during hypoglycemia. We would like to determine if a
diet supplemented with medium chain triglycerides can improve cognitive function during
hypoglycemia, diabetes control and also look at brain activity.
Hypoglycemia can be associated with confusion and disorientation as well as other symptoms
such as palpitations, sweating and tremors. Medium chain triglycerides (MCT) can be used as a
fuel in the brain during low blood sugar levels and therefore may prevent or reduce some of
the confusion and disorientation seen during hypoglycemia. We would like to determine if a
diet supplemented with medium chain triglycerides can improve cognitive function during
hypoglycemia, diabetes control and also look at brain activity.
30 subjects with well controlled type 1 diabetes will be recruited for the study. If you
agree to participate you will be scheduled for, dietitian visits, and a study visit which
will include insulin and glucose infusions, an MRI scan and brain function tests. All visits
will be on the Hospital Research Unit (HRU) on the 10th floor of Yale New Haven Hospital. You
will be randomized to either the MCT-supplemented diet or the standardized western diabetic
diet. If you are on the MCT diet, the MCT oil will be given to you and you will be shown how
to incorporate it into your diet. The MCT supplemented diet is for two weeks (with a two
gradual transition onto the diet) and the standardized western diet is for two weeks (with a
1 week transition onto the diet). At the end of the study you will be admitted to the
Hospital Research Unit for the insulin 'clamp' and MRI scan. A 'clamp' is a procedure which
involves insulin and glucose infusions. During a 'clamp' study, the insulin infusion is held
constant, while the glucose infusion is adjusted every 5 minutes as needed to maintain the
desired blood glucose levels. Compensation for the study is $750.
agree to participate you will be scheduled for, dietitian visits, and a study visit which
will include insulin and glucose infusions, an MRI scan and brain function tests. All visits
will be on the Hospital Research Unit (HRU) on the 10th floor of Yale New Haven Hospital. You
will be randomized to either the MCT-supplemented diet or the standardized western diabetic
diet. If you are on the MCT diet, the MCT oil will be given to you and you will be shown how
to incorporate it into your diet. The MCT supplemented diet is for two weeks (with a two
gradual transition onto the diet) and the standardized western diet is for two weeks (with a
1 week transition onto the diet). At the end of the study you will be admitted to the
Hospital Research Unit for the insulin 'clamp' and MRI scan. A 'clamp' is a procedure which
involves insulin and glucose infusions. During a 'clamp' study, the insulin infusion is held
constant, while the glucose infusion is adjusted every 5 minutes as needed to maintain the
desired blood glucose levels. Compensation for the study is $750.
Inclusion Criteria:
- type 1 diabetes
- HbA1c <8%
- BMI 18-30
- hypo unawareness
Exclusion Criteria:
- pregnancy
- significant diabetes complications
- liver disease, cirrhosis
- cardiac disease
- neurological disorder
- kidney disease
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