Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin



Status:Completed
Conditions:Hospital
Therapuetic Areas:Other
Healthy:No
Age Range:18 - Any
Updated:5/27/2013
Start Date:March 2011
End Date:September 2012
Contact:Michael Phillips, MD
Email:michael.phillips@nyumc.org
Phone:212-263-5454

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We hypothesize the application of mupirocin or povidone-iodine to the nares is equally
effective in short term Staphylococcus aureus(SA)suppression. Our overall study objective
is to measure the rate of deep and superficial Surgical Site Infections (SSIs) after primary
hip, knee, shoulder and elbow arthroplasty surgery and primary spinal fusion surgery
requiring implantation of prosthetic material, when the patient receives either nasal
mupirocin or nasal povidone-iodine prior to surgery.

Secondary study objectives include:

1. Measure hospital length of stay and re-admission rates in the mupirocin and
povidone-iodine groups.

2. Measure adverse events related to mupirocin and povidone-iodine.

3. Measure rate of SA resistance to mupirocin.


Inclusion Criteria:

- Primary arthroplasty or spinal fusion surgery

- Age greater than 18 years

Exclusion Criteria:

- Revision arthroplasty

- Revision spinal fusion surgery

- Primary spine surgery without implantation of prosthetic material

- Allergy to mupirocin

- Allergy to povidone-iodine

- Pregnancy

- Breastfeeding
We found this trial at
1
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550 1st Ave
New York, New York 10016
(212) 263-7300
New York University Langone Medical Center NYU NYU Langone Medical Center, a world-class, patient-centered, integrated,...
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