The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 1/6/2018 |
| Start Date: | April 2011 |
| End Date: | December 2018 |
| Contact: | Sukaynah Khetani, BS |
| Email: | sukaynah.khetani@ucsf.edu |
| Phone: | 415-353-4368 |
The hypothesis being tested is that in patients with stable claudication and documented PAD,
omega-3 supplementation for 1 month will lead to improvement in endothelial function as
measured by flow-mediated, brachial artery vasodilation (FMD), as well as improvement in the
vascular inflammatory profile as measured by a panel of established circulating inflammatory
biomarkers.
omega-3 supplementation for 1 month will lead to improvement in endothelial function as
measured by flow-mediated, brachial artery vasodilation (FMD), as well as improvement in the
vascular inflammatory profile as measured by a panel of established circulating inflammatory
biomarkers.
Inclusion Criteria:
- intermittent claudication
- resting or exercise Ankle-Brachial Index (ABI) <0.9
- age 50 and more
Exclusion Criteria:
- critical limb ischemia
- hypersensitivity/allergies to fish or seafood
- already on omega-3 fatty acids or equivalent
- significant renal, hepatic, and inflammatory disease
- concurrent severe infections
- acute illness (MI, stroke, major surgery within 30 days)
- receiving immunosuppressive medications or steroids
We found this trial at
1
site
San Francisco, California 94143
Principal Investigator: Marlene Grenon, MD
Phone: 415-221-4810
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